PRR11 Antibody, FITC conjugated

1. PRR11 plays an oncogenic role in hepatocellular carcinoma (HCC) progression, through activating the Wnt/beta-catenin signaling pathway, and may represent a valuable prognostic marker and therapeutic target for HCC. PMID:30248355
2. PRR11 positively regulated cell proliferation-related proteins, including c-myc and cyclin D1, and increased and decreased the expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 and PRR11 expression was mediated by the phosphoinositide 3-kinase/AKT/beta-catenin signaling pathway. PMID:30165366
3. these findings further illustrate the suppressive role of miR-195 in prostate cancer (PCa), and indicate a novel role of PRR11 in PCa. Importantly, the newly identified miR-195/PRR11 axis may aid with identifying potential therapeutic targets in PCa. PMID:29393495
4. PRR11 regulated self-renewal and tumorigenicity of gastric cancer stem cells through MAPK signaling, and could be used as a therapeutic target for gastric cancer. PMID:30007956
5. these findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in pancreatic cancer by targeting PRR11. PMID:28574724
6. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID:28257042
7. Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells. PMID:25971332
8. PRR11 may be widely activated in human gastric cancer. PMID:26252227
9. Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines. PMID:25973065
10. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID:26162986
11. Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation. PMID:25666944
12. our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer. PMID:23246489
13. the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed PMID:17672918

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HGNC: 25619

UNIGENE: Hs.631750

KEGG: hsa:55771

STRING: 9606.ENSP00000262293

OMIM: 615920