PRCP Antibody, FITC conjugated

Code: CSB-PA018636LC01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P42785

Target Names

PRCP

Alternative Names

Angiotensinase C antibody; HUMPCP antibody; Lysosomal carboxypeptidase C antibody; Lysosomal Pro X carboxypeptidase antibody; Lysosomal Pro-X carboxypeptidase antibody; MGC2202 antibody; PCP antibody; PCP_HUMAN antibody; PRCP antibody; Proline carboxypeptidase antibody; Prolylcarboxypeptidase (angiotensinase C) antibody; Prolylcarboxypeptidase antibody; prolylcarboxypeptidase isoform 1 preproprotein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Lysosomal Pro-X carboxypeptidase protein (347-443AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene References into Functions

For the first time, PRCP is identified as an apelin-cleaving enzyme. PMID:27449720
The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome PMID:25370794
PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation. PMID:25324000
The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population. PMID:22679278
PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID:23744584
analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID:22079761
PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells. PMID:21087932
A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid. PMID:20517885
Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution. PMID:20516604
A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7. PMID:20540760
Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients. PMID:20079160
PRCP appears to be a HUVEC-associated prekallikrein activator. PMID:11830581
Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. PMID:12123826
recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator. PMID:14996700
Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia PMID:16681991
role in regulation cardiovascular tone; proinflammatory agent PMID:18396440
These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion. PMID:18656443