PIK3R5 Antibody

Code: CSB-PA008386

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: WB, IHC, ELISA

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Target Background

Product Details

Uniprot NO.

Q8WYR1

Target Names

PIK3R5

Alternative Names

5-bisphosphate 3-kinase regulatory subunit antibody; F730038I15Rik antibody; FOAP 2 antibody; FOAP2 antibody; OTTHUMP00000135339 antibody; p101 antibody; P101 PI3K antibody; p101-PI3K antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody; Phosphoinositide 3 kinase, regulatory subunit 5 antibody; Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody; Phosphoinositide 3-kinase regulatory subunit 5 antibody; PI3 kinase p101 subunit antibody; PI3 kinase regulatory subunit 5 antibody; PI3-kinase p101 subunit antibody; PI3-kinase regulatory subunit 5 antibody; PI3R5_HUMAN antibody; PIK3 R5 antibody; PIK3R5 antibody; Protein FOAP 2 antibody; Protein FOAP-2 antibody; PtdIns 3 kinase p101 antibody; PtdIns 3 kinase regulatory subunit antibody; PtdIns-3-kinase p101 antibody; PtdIns-3-kinase regulatory subunit antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of Human PI 3-kinase p101.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.

Gene References into Functions

data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID:26173259
PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID:25374236
expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID:24014027
Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID:22065524
p101 has a role in membrane recruitment and activation of PI3K gamma PMID:12507995
analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID:15611065
Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID:17486067

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Subcellular Location

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.

Tissue Specificity

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.

Database Links

HGNC: 30035

UNIGENE: Hs.278901

KEGG: hsa:23533

STRING: 9606.ENSP00000392812

OMIM: 611317

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