PHIP Antibody, HRP conjugated

Code: CSB-PA837866LB01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q8WWQ0

Target Names

PHIP

Alternative Names

PHIP antibody; DCAF14 antibody; WDR11 antibody; PH-interacting protein antibody; PHIP antibody; DDB1- and CUL4-associated factor 14 antibody; IRS-1 PH domain-binding protein antibody; WD repeat-containing protein 11 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human PH-interacting protein (508-608AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene References into Functions

The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID:30018425
These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. PMID:24005052
The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. PMID:22511720

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed in myeloma and epidermoid carcinoma cell lines.

Database Links

HGNC: 15673

UNIGENE: Hs.511817

KEGG: hsa:55023

STRING: 9606.ENSP00000275034

OMIM: 612870

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