PARVA Antibody

Code: CSB-PA017474GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q9NVD7

Target Names

PARVA

Alternative Names

Actopaxin antibody; Alpha parvin antibody; Alpha-parvin antibody; Calponin like integrin linked kinase binding protein antibody; Calponin-like integrin-linked kinase-binding protein antibody; CH ILKBP antibody; CH-ILKBP antibody; FLJ10793 antibody; FLJ12254 antibody; Matrix remodelling associated 2 antibody; Matrix remodelling associated protein 2 antibody; Matrix-remodeling-associated protein 2 antibody; MXRA 2 antibody; MXRA2 antibody; PARV A antibody; Parva antibody; PARVA_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PARVA

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Gene References into Functions

edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype PMID:29386624
Protein expression of alpha-Parvin increases with colorectal cancer progression. PMID:26115385
PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma PMID:25738875
alpha-pv-deficient HUVECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell-extracellular matrix adhesion structures and an altered actin cytoskeleton. PMID:25925587
alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma PMID:24496929
Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs. PMID:23504997
beta2-adaptin is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner PMID:23056266
Actopaxin phosphorylation is required for matrix degradation and cell invasion via regulation of Rho GTPase signaling. PMID:22955285
results also identify the integrin-linked kinase (ILK) and alpha-parvin proteins as a new molecular partner and target, respectively, of the Lnk adaptor. PMID:22441983
the alpha-parvin CH2-paxillin LD1 complex has a role in focal adhesion assembly PMID:18508764
Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID:11722847
inhibition of the ILK-alpha-parvin complex is sufficient, although not necessary, for promotion of apoptosis PMID:15284246
Phosphorylation of actopaxin regulates cell spreading and migration. PMID:15353548
the association between actopaxin and TESK1, which is likely regulated by phosphorylation of actopaxin, regulates TESK1 activity and subsequent cellular spreading on fibronectin PMID:15817463
An unusual degree of binding degeneracy in the paxillin/alpha-parvin system that may facilitate the assembly of dynamic signaling complexes in the cell. PMID:18940607

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Subcellular Location

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.

Protein Families

Parvin family

Tissue Specificity

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.

Database Links

HGNC: 14652

UNIGENE: Hs.432914

KEGG: hsa:55742

STRING: 9606.ENSP00000334008

OMIM: 608120

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