PARP4 Antibody

Code: CSB-PA007321

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC, ELISA

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Target Background

Product Details

Uniprot NO.

Q9UKK3

Target Names

PARP4

Alternative Names

PARP4 antibody; ADPRTL1 antibody; KIAA0177 antibody; PARPL antibody; Protein mono-ADP-ribosyltransferase PARP4 antibody; EC 2.4.2.- antibody; 193 kDa vault protein antibody; ADP-ribosyltransferase diphtheria toxin-like 4 antibody; ARTD4 antibody; PARP-related/IalphaI-related H5/proline-rich antibody; PH5P antibody; Poly [ADP-ribose] polymerase 4 antibody; PARP-4 antibody; Vault poly(ADP-ribose) polymerase antibody; VPARP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human PARP-4.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Gene References into Functions

Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity PMID:28551640
PARP4 is a possible susceptibility gene of primary thyroid and breast cancer PMID:26699384
the protein levels of MVP, TEP1 and vPARP are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production. PMID:23739867
REVIEW:recent findings suggesting that PARP-1 participates in DNA damage signaling in cell death PMID:12829019

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.

Tissue Specificity

Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

Database Links

HGNC: 271

UNIGENE: Hs.744855

KEGG: hsa:143

STRING: 9606.ENSP00000371419

OMIM: 607519

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