NUDT2 Antibody

Code: CSB-PA2105ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P50583

Target Names

NUDT2

Alternative Names

2310051L06Rik antibody; 5''''-P1 antibody; AA939917 antibody; Ap4A hydrolase 1 antibody; Ap4A hydrolase antibody; AP4A_HUMAN antibody; Ap4Aase antibody; APAH 1 antibody; APAH1 antibody; Bis(5' nucleosyl) tetraphosphatase [asymmetrical] antibody; Bis(5''-nucleosyl)-tetraphosphatase [asymmetrical] antibody; Diadenosine 5'' antibody; Diadenosine 5',5''' P1,P4 tetraphosphate asymmetrical hydrolase antibody; Diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase antibody; Diadenosine tetraphosphatase antibody; EC 3.6.1.17 antibody; MGC10404 antibody; Nucleoside diphosphate linked moiety X motif 2 antibody; Nucleoside diphosphate-linked moiety X motif 2 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 2 antibody; Nudix motif 2 antibody; Nudix-type motif 2 antibody; NUDT 2 antibody; NUDT2 antibody; OTTHUMP00000021256 antibody; OTTHUMP00000021257 antibody; OTTHUMP00000021258 antibody; OTTHUMP00000021259 antibody; P4-tetraphosphate asymmetrical hydrolase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bis(5\\\'-nucleosyl)-tetraphosphatase [asymmetrical] protein (1-147AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA2105ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA2105ESR1HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.

Gene References into Functions

NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control. PMID:28089905
Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. PMID:27144453
This paper presents the crystal structure of wild-type and E58A mutant human Ap4A hydrolase. PMID:23384440
High NUDT2 is associated with breast carcinoma. PMID:20533549
In this study the authors present data demonstrating that the SARS-CoV 7a protein interacts with human Ap4A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17). PMID:20144233
crystallographic structure and substrate-binding mechanism of Ap4A hydrolase PMID:15596429
NMR resonance assignments PMID:15772762