NTRK3 Antibody

1. High TrkC mRNA expression appears to be frequent in the sonic hedgehog subgroup and seems not to have a major effect on therapy responsiveness in medulloblastoma patients. PMID:28695340
2. Data show that neurotrophin 3 receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC) cells, patients' tumor samples. PMID:28455963
3. LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR. PMID:27351280
4. Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 rearrangement and ETV6-NTRK3 gene fusion. PMID:27282352
5. The prevalence of ETV6-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population PMID:29046324
6. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion. PMID:26884591
7. 5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA/SDHx/RAS pathways, including two additional cases with FGFR1-TACC1 and ETV6-NTRK3 fusions, are reported. PMID:27974047
8. High expression of TrkC is associated with glioblastoma. PMID:28402394
9. Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer. PMID:28746220
10. we demonstrate the expression of the ETV6-NTRK3 fusion oncogene in a small subset of inflammatory myofibroblastic tumors PMID:27259007
11. ETV6-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly. PMID:28125451
12. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 gene fusion PMID:27631515
13. A subset of ALK-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism. PMID:26647767
14. TrkC-miR2 as a novel regulator of Wnt signaling, which might be a candidate oncogenic colorectal cancer biomarker. PMID:28100780
15. Pilot study usee targeted exome sequencing in an attempt to discover novel candidate genes related to Internet Gaming Disorder. Despite a relatively small sample, the targeted exome sequencing was feasible and valuable and revealed that rs2229910 of NTRK3 may be a protective SNP against Internet Gaming Disorder. PMID:27826991
16. Case Report: ETV6-NTRK3 translocation in primary cutaneous mammary analog secretory carcinoma. PMID:27763904
17. the ETV6-NTRK3 fusion might identify a subset of gastrointestinal stromal tumours with peculiar clinicopathological characteristics PMID:26606880
18. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID:26216473
19. SNPs in the NTRK3 gene, pain, physical activity, and fear of falling were directly associated with depressive symptoms in older adults. PMID:26055783
20. Molecular analysis of ETV6 gene rearranged mammary analogue secretory carcinoma of salivary glands tumors with lack of classical ETV6-NTRK3 fusion. PMID:26492182
21. Spectrum of secretory breast carcinoma with ETV6-NTRK3 gene fusion ranging from low-grade to high-grade histology, with occasional low hormonal receptor expression, simplex genomic profiles, and possible unfavorable course. PMID:26291510
22. The role of NTRK3 in in paranoid schizophrenia development in Russians. PMID:26410934
23. The overall percentage of NTRK3 gene methylation frequency with subsequent loss of mRNA expression was significantly higher in glioma compared with control samples. PMID:24840578
24. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. PMID:25772499
25. findings suggest a novel pathophysiological mechanism involving NTRK3 in the development of VSDs PMID:25196463
26. Report molecular genetic tests for ETV6-NTRK3 for differential diagnosis of mammary analogue secretory carcinoma of the salivary gland. PMID:25456394
27. ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis. PMID:24327398
28. NTRK3 genetic variants may influence white matter integrity in brain regions implicated in neuropsychiatric disorders. PMID:23727532
29. Results show that TrkC plays physiological role in the pathogenesis of leukemia and have important implications for understanding various hematological malignancies. PMID:23832765
30. Report ETV6-NTRK3 gene fusion in mammary analogue secretory carcinoma of salivary glands with high-grade transformation. PMID:24145651
31. our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms PMID:23874207
32. Genetic evidence shows that TrkC and TrkB activation in early cortical neurons depends on transactivation by epidermal growth factor receptor signaling. PMID:23416450
33. provide evidence that a mutation of TrkC detected in a sporadic cancer is a loss-of-proapoptotic function mutation PMID:23341610
34. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID:20078941
35. The significant expression of Trk isoforms among advanced neuroblastoma cases support their role as possible risk assessment tools alongside N-Myc amplification status. PMID:21728718
36. SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region. PMID:22265740
37. TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo. PMID:21788388
38. Low TRKC is associated with low vincristine and lomustine response in medulloblastoma. PMID:21617231
39. Mesenchymal stem cells modified by adenovirus carrying the TrkC gene are further promoted to differentiate into neuron-like cells with the potency of forming synapses by overexpressing the NT-3 gene in Schwann cells. PMID:19680743
40. We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. PMID:21401966
41. NT3 and its receptor may be involved in early folliculogenesis, particularly in the activation of primordial follicles. PMID:21392742
42. This study demonistrated that Intron 12 in NTRK3 is associated with bipolar disorder. PMID:20554328
43. Overexpression of TrkC is associated with breast tumor growth and metastasis. PMID:20802235
44. Findings suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and the EDN3 mutation acts as a phenotype modifier. PMID:19556619
45. Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes. PMID:19893451
46. Although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms. PMID:11877382
47. Expression of the ETV6-NTRK3 gene fusion is a primary event in human secretory breast carcinoma. PMID:12450792
48. ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID:14668342
49. While survival rates were higher for patients with high TrkC expression, these differences were not statistically significant. PMID:15198123
50. truncated trkC is prevalent in the human prefrontal cortex and that neurons and glia may be responsive to NT-3 throughout life PMID:15932601

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HGNC: 8033

UNIGENE: Hs.185701

KEGG: hsa:4916

STRING: 9606.ENSP00000354207

OMIM: 191316