NRG2 Antibody

Code: CSB-PA005145

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

O14511

Target Names

NRG2

Alternative Names

Divergent of neuregulin 1 antibody; Divergent of neuregulin-1 antibody; Don 1 antibody; DON-1 antibody; Neural- and thymus-derived activator for ERBB kinases antibody; Neuregulin 2 antibody; Neuregulin-2 antibody; NRG-2 antibody; Nrg2 antibody; NRG2_HUMAN antibody; NTAK antibody; Pro NRG2 antibody; Pro-NRG2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Neuregulin-2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of HT29 cells using Neuregulin-2 Polyclonal Antibody

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Target Background

Function(From Uniprot)

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Gene References into Functions

reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID:27345716
examination of the effect of isoforms on angiogenesis PMID:14722120
Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID:15961242
Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID:17563728
Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID:17945187
NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID:17962208