NLRP6 Antibody, FITC conjugated

Code: CSB-PA015874LC01HU

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US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P59044

Target Names

NLRP6

Alternative Names

Angiotensin II/vasopressin receptor antibody; AVR antibody; CLR11.4 antibody; NACHT, leucine rich repeat and PYD containing 6 antibody; NACHT, LRR and PYD containing protein 6 antibody; NACHT, LRR and PYD domains-containing protein 6 antibody; NAVR antibody; NAVR/AVR antibody; NLR family, pyrin domain containing 6 antibody; Nlrp6 antibody; NLRP6_HUMAN antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody; PAN3 antibody; PYPAF5 antibody; PYRIN containing APAF1 like protein 5 antibody; PYRIN-containing APAF1-like protein 5 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet. Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.

Gene References into Functions

this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease PMID:28214100
Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) PMID:28295271
Our results revealed an association between NLRP6/AVR and ADM loci with male essential hypertension, suggesting the existence of sex-specific NLRP6/AVR and ADM variants affecting male susceptibility to essential hypertension. PMID:24147025
NLRP6 is a newly characterized member of this family that inhibits NF-kappaB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. PMID:23811097
Studies identify AVR/NAVR as key receptors involved in blood pressure regulation and sex-specific modulation of renal water homeostasis, cognitive function, and anxiety-like behavior. PMID:20923861
AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns. PMID:18413781
The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. PMID:11984003
This publication deals with the rat ortholog of the human NLRP6 gene. PMID:7489366
PYPAF5 functions in immune cells to coordinate the transduction of pro-inflammatory signals to the activation of NF-kappaB and pro-caspase-1 PMID:12387869

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Subcellular Location

Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane.

Protein Families

NLRP family

Tissue Specificity

Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level).

Database Links

HGNC: 22944

UNIGENE: Hs.352611

KEGG: hsa:171389

STRING: 9606.ENSP00000309767

OMIM: 609650

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