NBR1 Antibody

Code: CSB-PA015508GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IF

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Product Details
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Target Background

Product Details

Uniprot NO.

Q14596

Target Names

NBR1

Alternative Names

1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human NBR1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Gene References into Functions

NBR1 is not required for PARK2-dependent mitophagy. PMID:26512954
The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID:26903539
NBR1 positively correlates with adipose inflammation in human obese patients. PMID:25043814
Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID:24879152
The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID:24769734
structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID:24692539
results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID:23239026
These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID:22484440
The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID:21121670
Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID:22728060
Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID:22430266
AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID:21606687
Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID:21620860
interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID:11856312
NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID:19398892
The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID:19427866
findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID:19822672