Ms4a1 Antibody, FITC conjugated

Code: CSB-PA015007LC01MO

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50μg100μg

US$166

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Species Reactivity: Mouse

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P19437

Target Names

Ms4a1

Alternative Names

Ms4a1 antibody; Cd20 antibody; Ly-44 antibody; Ms4a2 antibody; B-lymphocyte antigen CD20 antibody; B-cell differentiation antigen Ly-44 antibody; Lymphocyte antigen 44 antibody; Membrane-spanning 4-domains subfamily A member 1 antibody; CD antigen CD20 antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse B-lymphocyte antigen CD20 protein (111-291AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

FITC

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

Gene References into Functions

Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment PMID:28533311
Galectin-1 has a role in driving lymphoma CD20 immunotherapy resistance in a mouse model PMID:26888257
Results indicate that an antigen-specific B cell response towards intracellular pathogens can be generated during anti-CD20 depletion therapy. PMID:26261496
this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity. PMID:23966626
CD20 is required for store-operated calcium entry in C2C12 myoblasts. PMID:22982241
immunization of mice with the CD20 extracellular domain-6 using Freund's or QS-21 adjuvants was shown to exert significant biological effects in vivo with the pronounced depletion of splenic B cells. PMID:20189250
type I CD20 antibody cytotoxicity critically depends on Fc receptor ITAM signaling PMID:20354182
CD20 deficiency in humans results in impaired T cell-independent antibody responses. PMID:20038800
review of structure, function, tissue and cell distribution PMID:12144126
Anti-CD20 antibodies rapidly depleted the vast majority of circulating and tissue B cells in an isotype-restricted manner dependent on effector cell Fc receptor expression. PMID:15210744
expression in bacterial cells; isolation and biophysical and structural studies PMID:16285718
In mice treated with anti-CD20 mAb, development of arthritis was significantly reduced in comparison to control mAb-treated mice PMID:18354225
involvement of CD20 in calcium influx PMID:18474602