Mmp7 Antibody

Code: CSB-PA014677EA01RA

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20μg50μg100μg

US$83

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Species Reactivity: Rat, Mouse, Human

Raised in: Rabbit

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

P50280

Target Names

Mmp7

Alternative Names

Mmp7 antibody; Mmp-7Matrilysin antibody; EC 3.4.24.23 antibody; Matrin antibody; Matrix metalloproteinase-7 antibody; MMP-7 antibody; Pump-1 protease antibody; Uterine metalloproteinase antibody

Raised in

Rabbit

Species Reactivity

Rat, Mouse, Human

Immunogen

Recombinant Rat Matrilysin protein (98-267AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Mmp7 antibody at 2µg/ml
Lane 1: Colo320 whole cell lysaye
Lane 2: NIH/3T3 whole cell lysaye
Lane 3: Mouse lung tissue
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 30 kDa
Observed band size: 30 kDa

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Target Background

Function(From Uniprot)

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Gene References into Functions

Placental ischemia, possibly through the release of TNF-alpha, causes increases in the levels of matrix metalloproteinase (MMP)-1 and MMP-7, which could alter collagen deposition and cause inadequate uteroplacental and vascular remodeling in hypertension in pregnancy. PMID:28626073
Expression of MMP-7, c-Jun and c-Fos were increased in skin photoaging. PMID:23870463
Increased extracellular nerve growth factor precursor levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR). PMID:22238106
MMP-7 significantly contributes to intestinal epithelial wound closure. IL-1beta increased MMP-7 levels beyond those seen during normal healing. PMID:20655064
important role of MMP-2, MMP-9, and TIMP-4 in hypertensive remodeling of the cortex and medulla in the SHR rat PMID:12923405
Adrenergic alpha-agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. PMID:14656925
MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation. PMID:15894268
Diminished expression of MMP-7 may play a role in fibronectin accumulation in the diabetic kidney in response to advanced glycation end products and/or TGF-beta. PMID:17554258
Claudin-7, kidney injury molecule-1 (Kim-1), and matrix metalloproteinase-7 (MMP-7) changed by aging and changes attenuated by caloric restriction. PMID:17670906
These results suggest a novel role for noncanonical WNT signaling in maintaining kidney transplant tolerance with MMP7 being a key target. PMID:18209025
MMP-7 cleaves the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor to generate an N-terminal fragment of approximately 65 kDa PMID:18644839
Agonist signaling of both hypertension and hypertrophy depends on posttranscriptional and transcriptional mechanisms that involve MMP-7, which is transcriptionally connected with ADAM-12 PMID:19398663