MYL4 Antibody

Code: CSB-PA015311GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB

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Product Details
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Target Background

Product Details

Uniprot NO.

P12829

Target Names

MYL4

Alternative Names

ALC 1 antibody; ALC1 antibody; AMLC antibody; Atrial/embryonic alkali myosin light chain antibody; embryonic muscle/atrial isoform antibody; GT 1 antibody; GT1 antibody; MLC 1 antibody; MLC1 antibody; MYL 4 antibody; Myl4 antibody; MYL4_HUMAN antibody; Myosin atrial/fetal muscle light chain antibody; Myosin light chain 1 antibody; Myosin light chain 1 embryonic muscle/atrial isoform antibody; Myosin light chain 4 alkali atrial embryonic antibody; Myosin light chain 4 antibody; Myosin light chain alkali GT 1 isoform antibody; Myosin light chain alkali GT-1 isoform antibody; Myosin light polypeptide 4 alkali atrial embryonic antibody; Myosin light polypeptide 4 antibody; PRO1957 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human MYL4

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Regulatory light chain of myosin. Does not bind calcium.

Gene References into Functions

The authors describe in a population approach a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia. PMID:27742809
a novel, heterozygous p.Glu11Lys mutation in the atrial-specific myosin light chain gene MYL4, caused atrial fibrillation. PMID:27066836
A recessive frameshift mutation in MYL4 causes early-onset atrial fibrillation. PMID:25807286
results demonstrate that the expression of hALC-1 could have a beneficial effect on the overloaded hypertrophied heart PMID:16106982
The (Ala-Pro) rich part of this protein acts as a "spacer arm" responsible for correct positioning of the N-terminal actin binding site. PMID:9000508
The N-terminus of this protein is an actin binding site. PMID:9738905
NMR showed involvement of N-terminus and lysines 3 and 4 in interaction with actin. Mutations of these lysines (K3A,K4R,K4A,K4D) resulted in altered actin binding and actin activated MgATPase. Mutation of Ala-1 to val had no effect on binding or kinetics. PMID:10373429