MLLT4 Antibody

1. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID:29159771
2. AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors. PMID:29062045
3. miR-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells. PMID:27601590
4. Afadin (AFDN), a cytoskeletal and junction-associated protein, was present in 2D and 3D keratinocyte cultures, and validated as a so-far-unknown EphA2-interacting protein. PMID:27815408
5. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1-induced trans-activation of Snail, which promotes proliferation and metastasis. PMID:26013125
6. AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion. PMID:25879875
7. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID:23885123
8. The expression levels of CFTR and AF-6/afadin are significantly downregulated in human colon cancer tissues. PMID:24373847
9. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease. PMID:23393160
10. The interaction between the PDZ domain of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ-binding motif, was studied. PMID:20586101
11. Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin-ZO-1 interactions. PMID:21732359
12. the Necl-5-nectin, nectin-nectin, and nectin-afadin interactions cooperatively increase the clustering of the nectin-afadin complex at the cell-cell contact sites, promoting the formation of the nectin-based cell-cell adhesion. PMID:21880730
13. AF6/afadin is a marker of poor outcome in breast cancer, and its loss induces cell migration, invasiveness and tumor growth PMID:21478912
14. Results demonstrate a novel molecular mechanism by which Rap1 and afadin regulate the VEGF- and S1P-induced angiogenesis. PMID:20413783
15. RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. PMID:11956217
16. Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain PMID:12808105
17. Results report the solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. PMID:15684424
18. AF6 negatively regulates Rap1-induced cell adhesion. PMID:16051602
19. Loss of afadin is associated with breast cancer PMID:16819513
20. AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. PMID:17013812
21. c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations. PMID:17491594
22. AF6 protein is important for spreading of Herpes simplex virus 1 in epithelial cells PMID:17967423
23. two distal surfaces of the AF-6 PDZ domain respond differently to peptide binding; distal surface 1 changes in millisecond dynamics, whereas distal surface 2 undergoes structural rearrangement PMID:18052198
24. This paper deals with AF-6 in mouse, rat, and cow. PMID:9722616

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HGNC: 7137

UNIGENE: Hs.614974

KEGG: hsa:4301

STRING: 9606.ENSP00000375956

OMIM: 159559