MBD4 Antibody

1. Results demonstrated that MBD4 was downregulated, which lead to the overexpression and promoter hypomethylation of CD70 in CD4+ T cells from patients from systemic lupus erythematosus (SLE). This study preliminarily revealed the role and mechanism of MBD4 in the pathogenesis of SLE. PMID:29018507
2. these data suggest that MBD4 inactivation may contribute to tumorigenesis, acting as a modifier of mismatch repair-deficient cancer phenotype. PMID:26503472
3. MBD4 rs3138373 A>G and rs2005618 T>C single nucleotide polymorphisms were not associated with esophageal squamous cell carcinoma (ESCC) risk. rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly. PMID:25162968
4. Interaction between DNMT1 and MBD4 is involved in controlling gene expression and responding to oxidative stress. PMID:24434851
5. ERCC4 rs1800124 and MBD4 rs10342 non-synonymous single nucleotide polymorphism variants were associated with DNA repair capacity. PMID:24004570
6. the crystal structure of MBD4 bound to 5-hydroxymethylcytosine further demonstrates that MBDMBD4 is able to recognize a wide range of 5-methylcytosine modifications PMID:23316048
7. MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population. PMID:23027038
8. Crystal structures of human MBD4(catalytic domain) reveal that MBD4 uses a base flipping mechanism to specifically recognize thymine and 5-hydroxymethyluracil. PMID:22848106
9. specificity of MBD4 for acting at CpG sites depends largely on its methyl-CpG-binding domain, which binds preferably to G.T mispairs in a methylated CpG site PMID:22560993
10. MBD4-8666 and MBD4-9229, but not MBD4-1057, gene polymorphisms are related to rheumatoid arthritis in Chinese patients in Taiwan. PMID:20676650
11. MBD 4--a potential substrate for protein kinase X PMID:21971312
12. the crystal structure of C-terminal glycosylase domain of human MBD4 was determined. PMID:21820404
13. decreased expression in patients with primary immune thrombocytopenia PMID:21377502
14. Data suggest that methyl-CpG binding domain 4 polymorphism may not be a stratification marker to predict the susceptibility to immune thrombocytopenic purpura, at least in the Chinese population. PMID:20100009
15. MBD4 expression is associated with grade of malignancy in gliomas PMID:11836615
16. results indicate the formation of a complex with the estradiol receptor PMID:12220634
17. Frameshift mutations were found in 29% of gastric and 20% of colon MSI-H cancers, but not in any low-frequency microsatellite instability/microsatellite stable cancers. PMID:12430186
18. MBD4 mutations were found in 15% MSI but not in MSS colrectal tumors. PMID:12926109
19. MBD4 acts as a repressor protein binding to hypermethylated promoters of the p16(INK4a) and hMLH1 genes. PMID:15899845
20. MBD4 Glu346Lys polymorphism could be used as a marker for genetic susceptibility to adenocarcinoma of the lung. PMID:16803845
21. Mutations in MBD4 are unlikely to be implicated in HPS. PMID:16831587
22. These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex. PMID:17049487
23. The overexpression of MBD4(tru) in Big Blue (lacI)-transfected, MSI human colorectal carcinoma cells doubled mutation frequency, indicating that the modest dominant negative effect on DNA repair can occur in living cells in short-term experiments. PMID:17285135
24. MBD2 and MBD4 transcript overexpression and inverse correlations with DNA methylation indices indicate that both enzymes may really have a direct and active role on the genome-wide DNA hypomethylation observed in CD4+ T cells from SLE patients. PMID:17360956
25. Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. PMID:18162445
26. Single nucleotide polymorphisms in MBD4 are associated with lung cancer. PMID:18495292
27. MBD4 efficiently processed T/G mismatches within the nucleosome. PMID:18519584
28. The methyl binding domain of MBD4/MED1 was found to specifically inhibit the activity of MBD4/MED1 as well as the glycosylase domain, when the G:IU mispairs were located in a methylated CpG context. PMID:19395862
29. The Glu346Lys polymorphism and frameshift mutations of the Methyl-CpG Binding Domain 4 gene is associated with gastrointestinal cancer PMID:19469655

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HGNC: 6919

UNIGENE: Hs.35947

KEGG: hsa:8930

STRING: 9606.ENSP00000249910

OMIM: 603574