MBD1 Antibody

1. MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1. PMID:28473981
2. Our findings imply that reduced stability and enhanced dynamics of MBD1 or MBD6 is the origin of ATP7B dysfunction in Wilson disease patients with the G85V or G591D mutation. PMID:27744583
3. MBD1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. PMID:28449087
4. the binding of MBD1 to nucleosomes demonstrates sequence preferences depending on the position of the methyl groups on the nucleosome. PMID:28377300
5. c-myc plays a key role in MBD1 mediated epigenetic silencing of KEAP1. PMID:26980696
6. Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 protein. PMID:25658035
7. MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III. PMID:25798578
8. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. PMID:24849540
9. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance PMID:24464130
10. an important function of MBD1 in DNA repair and mediation of chemoradioresistance of cancer cells PMID:23588667
11. higher MBD1 expression correlated with lymph node metastasis and poor survival in pancreatic cancer; gain- and loss-of-function studies in vitro validated MBD1 as a potent oncogene promoting pancreatic cancer cell invasion and epithelial-mesenchymal transition PMID:23331011
12. MBD1-containing chromatin associated factor 2, epithelial malignancy-related vimentin and exocytosis-related annexin A2 were changed upon exposure to airborne nanoparticle PM(0.056). PMID:21491466
13. This review tries to match MeCP2 structural domains, or their lack, and specific chromatin features needed for proper recruitment of MeCP2 to its functions as either activator or repressor. We specifically focused on MeCP2's role in Rett syndrome PMID:21326358
14. lack of binding to mCpG and interaction with NuRD/Mi2 components HDAC1 and MTA2 PMID:12124384
15. investigation of role of specific mutations in autism PMID:12384770
16. Results show that methyl-CpG binding domain protein 1 (MBD1) is expressed in tumor cells, but methyl-CpG binding domain protein 2 (MBD2) and methyl CpG binding protein 2 (MeCP2) are not. PMID:12646234
17. MCAF interacts with the transcriptional repression domain of MBD1 PMID:12665582
18. Suv39h1 enhanced MBD1-mediated transcriptional repression via MBD, not the C-terminal transcriptional repression domain of MBD1. MBD1 links to histone deacetylases through Suv39h1, causing methylation and deacetylation of histones for gene inactivation PMID:12711603
19. Additional evidence of variable expression in the Rett disorder phenotype is presented by a small mixed gender group of children with autistic disorder. PMID:12770674
20. role in chromatin compaction PMID:12788925
21. determination of link of p59 OASL with MBD1 transcriptional control in the context of an interferon-stimulated cell, and provision of basis for future studies to examine the functional role of this interaction PMID:14728690
22. regulates G1-S transition and apoptosis via p53/p21(Waf1) pathway PMID:15081425
23. Data show that the methyl-CpG binding protein MBD1 forms a stable complex with histone H3-K9 methylase SETDB1. PMID:15327775
24. These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2. PMID:15691849
25. Methyl-CpG binding protein MBD1 binds to teneurin 1. PMID:15777793
26. PML-RARalpha functions by recruiting an HDAC3-MBD1 complex that contributes to the establishment and maintenance of the silenced chromatin state PMID:16432238
27. MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification PMID:16757475
28. Sex-specific time windows for concomitant upregulation of MBD1 are associated with prenatal remethylation of the human male and female germ line. PMID:16998846
29. Transcriptional silencing by MBD1 is regulated by a PIAS-mediated conjugation of SUMO1, which antagonizes the formation of a repressive complex with SETDB1. PMID:17066076
30. MBD1 and Polycomb group proteins have overlapping roles in epigenetic gene silencing and heterochromatin foci formation through their interactions. PMID:17428788
31. some insight into the functional mechanism of MBD1 in the development of pancreatic cancer PMID:18445260
32. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes PMID:18666890
33. Results suggest that MBD1 polymorphisms might be involved in the development of lung cancer in Chinese population. PMID:18668384

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HGNC: 6916

UNIGENE: Hs.405610

KEGG: hsa:4152

STRING: 9606.ENSP00000405268

OMIM: 156535