MAPK11 (Ab-180/182) Antibody

1. The two kinases HIPK3 and MAPK11 effect on Huntingtin (HTT)levels are mutant HTT protein (mHTT)-dependent, providing a feedback mechanism in which mHTT enhances its own level thus contributing to mHTT accumulation and disease progression. PMID:29151587
2. Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity. PMID:26976637
3. p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis. PMID:26666822
4. Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling. PMID:27029009
5. These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. PMID:25936522
6. The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder. PMID:25918994
7. p38beta is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells. PMID:23807508
8. Data show that the p38 MAPK (p38) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell. PMID:25066918
9. Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers. PMID:24673557
10. study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells PMID:25006254
11. Study identifies Hsp27 as a novel target of ILK-p38beta signaling complexes, playing a key role in bladder cancer cell migration. PMID:23435415
12. Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling PMID:22522454
13. Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. PMID:22157753
14. results demonstrate that IFN-alpha can regulate growth inhibition of Jurkat cells through p38alpha and p38beta PMID:20053787
15. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production PMID:20378550
16. These results demonstrate that activin A induces erythroid differentiation of K562 cells through activation of MKK6-p38alpha/p38beta pathway and follistatin inhibits those effects. PMID:20162623
17. show that p38 MAP kinase directly activates TACE and effects shedding in response to growth factors and Erk MAP kinase activation. PMID:20188673
18. p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating PMID:12384504
19. the p38MAPK activation-Bax expression pathway might be involved in apoptosis induced by oxidative stress PMID:12510156
20. Neurotoxicity of pneumolysin depends on activation of p38 mitogen-activated protein kinase. PMID:12586546
21. activation of p38 MAPK is involved in the mitochondrial activation-mediated cell death pathway PMID:14522966
22. SAPK2/p38 intervenes in the control of MonoMac6 cell migration induced by monocyte chemoattractant protein-1. PMID:14688370
23. phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF PMID:14724572
24. SAPK2/p38 mitogen-activated protein kinase is inhibited by PML in tumor cells PMID:15273249
25. cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta. PMID:15304097
26. p38SAPK might be involved in the regulation of cyclin D3 levels and suggest that this mechanism is involved in the maturation of precursor T-cells PMID:15326477
27. p38alpha and -beta mediate UV-induced, AP-1-mediated, c-Fos phosphorylation PMID:15708845
28. p38 phosphorylation occurred in response to attack by Staphylococcus aureus alpha-toxin and streptolysin O, commencing within minutes after toxin treatment and waning after several hours. PMID:16643845
29. The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase. PMID:18950637
30. genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase PMID:19082897
31. Specific isoforms of p38 and their sub-cellular localization may have different roles in modulating ischemic injury. PMID:19706373

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