MAGEA2 Antibody

CSB-PA013327LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

P43356

Target Names

MAGEA2

Alternative Names

MAGEA2 antibody; MAGE2 antibody; MAGEA2A; antibody; MAGEA2B antibody; MAGE2 antibody; MAGEA2 antibody; Melanoma-associated antigen 2 antibody; Cancer/testis antigen 1.2 antibody; CT1.2 antibody; MAGE-2 antigen antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: K562 whole cell lysate, Raji whole cell lysate
All lanes: MAGEA2 antibody at 4.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa

Description

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Target Background

Function

Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Subcellular Location

Nucleus. Nucleus, PML body.

Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Database Links

HGNC: 6800

UNIGENE: Hs.534597

KEGG: hsa:266740

STRING: 9606.ENSP00000359307

OMIM: 300173

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