LGALS4 Antibody

CSB-PA012889LA01HU

Rate （N/A）
Review （0）

Size:

20μl50μl100μl

US$83

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC, IF

Send an Inquiry

Start an on-line Chat

Orders can only be placed from within the U.S.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

P56470

Target Names

LGALS4

Alternative Names

Antigen NY CO 27 antibody; Antigen NY-CO-27 antibody; Antigen NYCO27 antibody; GAL 4 antibody; Gal-4 antibody; GAL4 antibody; Galectin 4 antibody; Galectin-4 antibody; Galectin4 antibody; Homo sapiens galectin4 mRNA complete cds antibody; L 36 lactose binding protein antibody; L-36 lactose-binding protein antibody; L36 lactose binding protein antibody; L36LBP antibody; Lactose binding lectin 4 antibody; Lactose-binding lectin 4 antibody; Lectin galactoside binding soluble 4 antibody; LEG4_HUMAN antibody; LGALS4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Galectin-4 protein (1-323AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-4 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-PA012889LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of A549 cells with CSB-PA012889LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Description

The Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal antibody is produced in rabbits using Recombinant Human Galectin-4 protein (1-323AA). It is validated for ELISA, IF, and IHC. This antibody reacts with Human Galectin-4 (LGALS4), a protein involved in intracellular and intercellular interactions.
Galectin-4 belongs to a family of proteins that bind to beta-galactoside. It plays a role in cancer and inflammatory diseases of the intestine.
The levels of Galectin-4 in the body have been shown to rise as cancer progresses, making it a possible tumor marker. In inflammatory diseases of the intestine, Galectin-4 stimulates the production of mediators that worsen inflammation.
The Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal Antibody can be used in research to detect the presence of Galectin-4, a possible tumor marker.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Gene References into Functions

Data show that galectin-4 expressing tumor cells interact directly with red blood cells (RBCs). PMID:28293788
Haplotype formed from two promoter SNPs rs116896264 and rs73933062 is associated with galectin-4 overexpression in colorectal cancer. PMID:26681582
LGALS4 may function as a tumor suppressor gene in UC progression. Findings provide evidence that methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression. PMID:28423602
Together, the data demonstrated that surface-bound galectin-4 is a dual function protein-down-regulating cell proliferation and chemokine secretion in galectin-4-expressing colorectal cancer cells on one hand and inducing apoptosis in galectin-4-negative colorectal cancer cells on the other hand. PMID:28345468
The carbohydrate-binding site is composed of residues His236, Asn238, Arg240, Asn249, Trp256, Glu259 and Lys261 at the strands S4, S5 and S6. PMID:26432949
The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID:26505429
The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID:26481311
Structural characterization of human galectin 4 C-terminal domain in terms its ligands binding specificity has been reported. PMID:26077389
role in basolateral to apical epithelial transcytosis PMID:25179596
The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients. PMID:25230111
Galectin-4 plays an important role in metastatic process of lung adenocarcinoma. PMID:24339976
Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling. PMID:23378274
Loss of Galectin-4 is associated with colorectal cancer. PMID:21064109
crystals of galectin-4 belonged to space group P6(1)22, with unit-cell parameters a = b = 71.25, c = 108.66 A. PMID:20445255
microarray study in sinonasal adenocarcinoma we identified proteins, LGALS4 that is significantly differentially expressed in tumors compared to normal tissue PMID:19903339
results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans PMID:11971864
SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4 PMID:15546874
Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery. PMID:15883199
Galectin 4 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID:16940423
not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo PMID:17545668
chemical analysis of talose-selectivity of galectin-4 and galectin-8 PMID:18539029
Data show that the pattern of N-glycosylation of glycoproteins serves as a recognition signal for endocytosed galectin-4, which drives the raft-dependent apical pathway of glycoproteins in enterocyte-like HT-29 cells. PMID:19192249