KIR2DS5 Antibody, HRP conjugated

Code: CSB-PA619902LB01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q14953

Target Names

KIR2DS5

Alternative Names

KIR2DS5 antibody; CD158G antibody; NKAT9Killer cell immunoglobulin-like receptor 2DS5 antibody; CD158 antigen-like family member G antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 9 antibody; NKAT-9 antibody; CD antigen CD158g antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Killer cell immunoglobulin-like receptor 2DS5 protein (162-242AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.

Gene References into Functions

KIR2DS5 gene may be protective against hypertension. PMID:29105364
The presence ofKIR2DS5 reduced the risk of endometriosis if a female possessed alleles from group C2 of HLA-C. PMID:25724317
The presence of KIR2DS2/2DL2 with KIR2DS5 abrogated the risk of KIR2DS2/2DL2 and the protective benefit of KIR2DS5. PMID:24571473
genetic polymorphism impacts glycosylation and protein expression level PMID:24269691
The activating KIR2DS5 gene was significantly increased in thyroid ancer patients compared to the controls. PMID:22836040
Data indicate that killer-cell immunoglobulin-like receptors (KIRs)activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes are associated with severe pandemic influenza A (H1N1) 2009 infections. PMID:22652695
In summary, KIR polymorphisms may be involved in the development of Epstein-Barr virus associated hemophagocytic lymphohistiocytosis, with KIR2DS5 promoting susceptibility to this disease. PMID:22376216
increase in the allele distribution in northern province of Tehran compared with that reported for the southern Iran population PMID:21867738
predisposition to systemic lupus erythematosus was associated with GTGT deletion at the SLC11A1 3'UTR, presence of KIR2DS2 +/KIR2DS5 +/KIR3DS1 + profile, increased number of stimulatory KIR genes and European and Amerindian ancestries PMID:21233146
The presence of KIR2DS5 gene protects human from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. PMID:20865034
reduced allele frequency in African Americans PMID:19410616
Donor activating KIR2DS5 may improve disease-free survival in non T-cell-depleted haploidentical hematopoietic stem cell transplantation. PMID:18315912
Positive linkage disequilibrium was seen and between KIR3DS1 and KIR2DS5. PMID:12559621
Carriage of activating 2ds5 was increased in patient with herpes virus RDs. PMID:17592337
The most frequent allele found in 132 cell lines from International Workshop samples is KIR2DS5*005, an allele characteristic of African populations. PMID:18498296
The stimulatory KIR2DS5 gene was associated with improved leukemia free survival. PMID:18555529
KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. PMID:18624290
The level of KIR2DS5 surface expression was impacted by residue 47 but that variation at several residues in the D2 domain of KIR2DS5 ultimately had a more profound effect. PMID:18682925
Lack of activation KIR2DS5 may play an important role in the development of bronchiolitis obliterans but not in the control of cytomegalovirus reactivation after lung transplantation. PMID:18765192
KIR2DS1 incompatibilities increased risk of relapse after allogeneic hematopoietic stem cell transplantation PMID:19500138