KCNIP4 Antibody, HRP conjugated

Code: CSB-PA750882LB01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q6PIL6

Target Names

KCNIP4

Alternative Names

A type potassium channel modulatory protein 4 antibody; A-type potassium channel modulatory protein 4 antibody; CALP antibody; Calsenilin like protein antibody; Calsenilin-like protein antibody; HGNC:30083 antibody; KCHIP 4 antibody; KChIP4 antibody; KCIP4_HUMAN antibody; KCNIP 4 antibody; Kcnip4 antibody; Kv channel interacting protein 4 antibody; Kv channel-interacting protein 4 antibody; MGC44947 antibody; Potassium channel interacting protein 4 antibody; Potassium channel-interacting protein 4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kv channel-interacting protein 4 protein (1-250AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Gene References into Functions

Results indicate that SNPs in KCNIP4 may modulate ACE inhibitor-induced cough risk. PMID:26169577
Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. PMID:24811166
genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders. PMID:22981920
Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse. PMID:23457522
KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID:23576435
The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels. PMID:21624954
These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a. PMID:20045463
cloning and investigation of interaction with presenilin 2 and voltage-gated potassium channel subunit Kv4 PMID:11847232
The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure. PMID:16951992
Mutation of KCNIP4 is associated with renal cell carcinoma. PMID:17981209
CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID:18269347
These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID:18393943
KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID:18957440