IL17C Antibody

Code: CSB-PA301181

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC,ELISA

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Target Background

Product Details

Uniprot NO.

Q9P0M4

Target Names

IL17C

Alternative Names

CX2 antibody; Cytokine CX2 antibody; IL 17C antibody; IL 21 antibody; IL-17C antibody; IL17C antibody; IL17C_HUMAN antibody; Interleukin 17C antibody; Interleukin-17C antibody; MGC126884 antibody; MGC138401 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide from Human protein at AA range: 81-130

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IHC,ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Images

Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200

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Target Background

Function(From Uniprot)

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Gene References into Functions

Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID:26989880
Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID:28739826
Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID:28346430
CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID:26472015
Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID:25012243
IL-17C is an essential epithelial cell-derived cytokine. PMID:23944933
Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID:23892590
Interleukin-17C is present in the tissue around aseptic loosened implants. PMID:23474800
IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID:23221046
Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID:22994872
Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID:23359500
In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID:22506826
IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID:21993848
activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID:21628458
expressed in multiple sclerosis brain lesions PMID:11984595