IL12B Antibody

Code: CSB-PA011587LA01SH

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20μg50μg100μg

US$83

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Species Reactivity: Sheep

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

P68220

Target Names

IL12B

Alternative Names

IL12B antibody; Interleukin-12 subunit beta antibody; IL-12B antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; CLMF p40 antibody; IL-12 subunit p40 antibody

Raised in

Rabbit

Species Reactivity

Sheep

Immunogen

Recombinant Sheep Interleukin-12 subunit beta protein (23-327AA)

Immunogen Species

Ovis aries (Sheep)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.; Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene References into Functions

The aim of the study was to assess the prognostic significance of Tumor Necrosis Factor-alpha, Interleukin-12(p40), Interleukin-6 and Interleukin 10 levels in cerebrospinal fluid (CSF) in sheep with encephalitic listeriosis. PMID:25817420
Local intraocular production of IL-12 p40 (but not IL-4) prolongs corneal graft survival significantly PMID:16081789

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Subcellular Location

Secreted.

Protein Families

Type I cytokine receptor family, Type 3 subfamily

Database Links

UNIGENE: Oar.721

KEGG: oas:443472

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