IFITM1 Antibody, Biotin conjugated

1. Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation PMID:27552157
2. Using a multi-group heat map from GSE9716 analysis of the GEO database, IFITM1 was determined to be a relevant radioresistance gene. Inhibition of IFITM1 in combination with radiotherapy could, indeed, inhibit oral neoplasm cells. PMID:29770536
3. Inactivated viral particle inoculation increased the expression of IFITM1protein at mRNA and protein levels, and mediated the antiviral state in HUVECs. PMID:29100522
4. Identification of three distinct mutations that converted IFITM1 or IFITM3 from inhibitors to enhancers of MERS-CoV or SARS-CoV spike protein-mediated entry revealed key structural motifs or residues determining the biological activities of IFITM proteins. PMID:29263263
5. Epithelial-mesenchymal transition (EMT) signature was dysregulated by both loss and gain of function of IFITM1, which was partially reverted by Caveolin-1 (CAV1). PMID:27852071
6. These results indicate that IFITM1 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes. PMID:27219333
7. The transcriptional regulation of IFITM1, 2 and 3 expression. PMID:28511927
8. IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. PMID:27268505
9. IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT1-mediated induction of p21. PMID:28411130
10. Compared with CD10, IFITM1 has superior performance distinguishing endometrial stroma of adenomyosis from mesenchyma surrounding invasive endometrial adenocarcinoma. PMID:27124937
11. Overexpression of IFITM1 is associated with Oral Squamous Cell Carcinomas. PMID:27221933
12. High expression of IFITM1 is associated with poor prognosis of colorectal cancer. PMID:26884876
13. These findings indicate that overexpression of IFITM1 enhances the aggressive phenotype of triple-negative SUM149 IBC cells and that this effect is dependent on STAT2/BRG1 interaction. PMID:26897526
14. propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific PMID:26354436
15. the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization. PMID:25738301
16. Suggest that IFITM1 promotes the aggressiveness of colorectal cancer cells via caveolin-1 signaling. PMID:26259513
17. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into HIV-1 viral particles. PMID:25422070
18. Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread. PMID:25464829
19. Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly. PMID:25552713
20. Schizophrenia subjects with higher IFITM mRNA levels in cortical blood vessels have greater disturbances in cortical GABA neurons suggests that these cell-type disturbances might be influenced by a shared upstream insult that involves immune activation. PMID:24209773
21. IFITM1 could be a novel metastasis-promoting gene that enhances the metastatic phenotype in ovarian cancer via epigenetic transcriptional regulation. PMID:24676393
22. IFITM1 is a potential valuable addition to immunohistochemical panels used in the diagnosis of cellular mesenchymal uterine tumors. PMID:24072182
23. Results suggest that the g.-1920G>A polymorphism in interferon inducible transmembrane protein 1 (IFITM1) may be associated with susceptibility to ulcerative colitis (UC). PMID:24120510
24. IFITM1 is essential for the formation of functional blood vessels and stabilizes EC-EC interactions during endothelial lumen formation by regulating tight junction assembly. PMID:24603679
25. Although their inhibitory activities were modest when compared to that of tetherin, IFITMs, but not tetherin, directly reduced the expression of HIV-1 proteins including Gag, Vif and Nef. PMID:23376165
26. Authors show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family. PMID:23720721
27. This study defines IFITM1 as an interferon-stimulated gene effector with action against HCV entry. PMID:22996292
28. IFITM1 knockdown in human alveolar-derived bone marrow stromal cells was associated with inhibition of Runx2 mRNA and protein expression. PMID:22634173
29. Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a. PMID:22787204
30. The results suggest that the expression of IFITM1 controls the invasiveness and migration of gastric cancer. PMID:22609115
31. Hepatitis C virus infection suppresses the upregulation of a subset of effector molecules, including ISG56 and IFITM1. PMID:21976647
32. IFITM1 was expressed in the five human glioma cell lines, and its expressions were positively correlated with their tumorigenicity PMID:20838853
33. IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. PMID:21253575
34. IFITM1, IFITM2, and IFITM3 inhibit HIV-1 replication through interfering with virus entry. PMID:21177806
35. Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID:20220060
36. Activated IFITM1 is associated with Peutz-Jeghers syndrome polyps. PMID:20428811
37. Down regulation of IFITM1 is associated with cervical squamous cell carcinoma. PMID:20099975
38. The positive expression level of IFITM1 is associated with the progression of the carcinogenetic process in Peutz-Jeghers syndrome. PMID:19304549
39. LEU13 has a novel role different from that in the inhibition of cell proliferation, involved in IFNA-induced refractoriness of RSa cells to X rays PMID:12926988
40. IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival PMID:15661263
41. Overexpression of 9-27 leads to increased migration and invasiveness by suppressing natural killer cells in gastric cancer PMID:15808405
42. IFITM1 has a role in cellular sensitivity to CDDP in esophageal cancer PMID:18202764
43. IFITM1 plays an important role for the invasion at the early stage of HNSCC progression PMID:18829488
44. results revealed that the interaction between IFITM1 and CAV-1 could enhance the inhibitory effect of CAV-1 on ERK activation PMID:19499152
45. Antiviral effect of IFITM family members on H1N1 influenza, West Nile virus, and Dengue virus PMID:20064371

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HGNC: 5412

UNIGENE: Hs.458414

KEGG: hsa:8519

STRING: 9606.ENSP00000330825

OMIM: 604456