GRM8 Antibody

CSB-PA009035

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, IHC, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

O00222

Target Names

GRM8

Alternative Names

FLJ41058 antibody; GLUR8 antibody; Glutamate receptor metabotropic 8 antibody; GPRC1H antibody; GRM8 antibody; GRM8_HUMAN antibody; Metabotropic glutamate receptor 8 antibody; MGC126724 antibody; mGlu8 antibody; mGluR8 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human mGluR-8.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol

Datasheet & COA

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Description

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Target Background

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene References into Functions

This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence). PMID:27871913
These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. PMID:25978827
Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region. PMID:25918841
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8). PMID:24821406
The GRM8 gene might play an important role in the pathogenesis of schizophrenia. PMID:25588301
Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain PMID:23420844
Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID:21493956
Pias1 binds to and sumoylates metabotropic glutamate receptor 8 PMID:16144832
GRM8 genes are likely involved in the pathogenesis of autistic disorder. PMID:17955477
Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported. PMID:18618593