GRM4 Antibody

Code: CSB-PA923348

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,IHC

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Target Background

Product Details

Uniprot NO.

Q14833

Target Names

GRM4

Alternative Names

Glutamate receptor metabotropic 4 antibody; GPRC1D antibody; Grm4 antibody; GRM4_HUMAN antibody; Metabotropic glutamate receptor 4 antibody; mGlu4 antibody; mGluR4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human GRM4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA923348(GRM4 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

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Target Background

Function(From Uniprot)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Gene References into Functions

EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID:29339716
Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID:27792966
Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID:26276359
The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID:24984297
study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID:24840839
The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID:24925192
explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID:25342125
Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID:20826542
GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID:20338729
residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID:15184361
mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID:15217955
Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID:15867225
mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID:16582932
These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID:16899734
the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID:17884634