GRIN2D Antibody

Code: CSB-PA009915ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB

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Product Details
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Target Background

Product Details

Uniprot NO.

O15399

Target Names

GRIN2D

Alternative Names

EB11 antibody; estrogen receptor binding CpG island antibody; GluN2D antibody; Glutamate [NMDA] receptor subunit epsilon 4 antibody; Glutamate [NMDA] receptor subunit epsilon-4 antibody; Glutamate receptor ionotropic antibody; glutamate receptor ionotropic NMDA 2D antibody; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D antibody; Grin2d antibody; N methyl D aspartate receptor subtype 2D antibody; N methyl d aspartate receptor subunit 2D antibody; N-methyl D-aspartate receptor subtype 2D antibody; NMDA 2D antibody; NMDAR2D antibody; NMDE4 antibody; NMDE4_HUMAN antibody; NR2D antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glutamate receptor ionotropic, NMDA 2D protein (330-480AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: GRIN2D antibody IgG at 3.65μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 144 kDa
Observed band size: 144 kDa

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Target Background

Function(From Uniprot)

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.

Gene References into Functions

This study found that NMDAR activation, NR2D in particular, is involved in human fetal lung fibroblast proliferation and collagen production through a potential ERK1/2-mediated mechanism. PMID:28987794
High GRIN2D expression is associated with colorectal cancer. PMID:26943033
This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals. PMID:28284346
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers PMID:27616483
After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics. PMID:22486492
Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls. PMID:22833210
In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis. PMID:21915661
data show that the NMDAR2D was specifically expressed in cultivated keratinocytes PMID:16328341