GRIA4 Antibody

Code: CSB-PA008959

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50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, IHC, ELISA

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Target Background

Product Details

Uniprot NO.

P48058

Target Names

GRIA4

Alternative Names

AMPA 4 antibody; AMPA selective glutamate receptor 4 antibody; AMPA-selective glutamate receptor 4 antibody; AMPA4 antibody; GluA 4 antibody; GluA4 antibody; GluR 4 antibody; GluR D antibody; GluR-4 antibody; GluR-D antibody; GluR4 antibody; GLUR4C antibody; GLURD antibody; Glutamate receptor 4 antibody; Glutamate receptor ionotrophic AMPA 4 antibody; Glutamate receptor ionotropic antibody; GRIA 4 antibody; Gria4 antibody; GRIA4_HUMAN antibody; Ionotropic Glutamate receptor 4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Human GluR4 around the non-phosphorylation site of S862.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

WB, IHC, ELISA

Protocols

Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of NIH-3T3 cells using GluR4 Polyclonal Antibody

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene References into Functions

The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID:29220673
Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID:27443784
This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID:25433904
Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID:24962026
Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID:22057216
SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID:22122651
No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID:22094384
characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID:12393905
Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID:12497607
alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID:15306133
The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID:15823042
GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID:16190873
The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID:17233759

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily

Database Links

HGNC: 4574

UNIGENE: Hs.503743

KEGG: hsa:2893

STRING: 9606.ENSP00000282499

OMIM: 138246

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