GPR64 Antibody

CSB-PA912224

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8IZP9

Target Names

ADGRG2

Alternative Names

ADGRG2 antibody; GPR64 antibody; HE6 antibody; TM7LN2Adhesion G-protein coupled receptor G2 antibody; G-protein coupled receptor 64 antibody; Human epididymis-specific protein 6 antibody; He6 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human GPR64

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Datasheet & COA

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Images

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA912224(GPR64 Antibody) at dilution 1/55, on the right is treated with synthetic peptide. (Original magnification: ×200)

Description

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Target Background

Function

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.

Gene References into Functions

identified two missense variants in two congenital bilateral absence of the vas deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR variants, implying the ADGRG2 variants are the genetic cause in these patients PMID:28805948
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. PMID:27760455
study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect PMID:27476656
Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB. PMID:26321231

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Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Tissue Specificity

Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specific

Database Links

HGNC: 4516

UNIGENE: Hs.146978

KEGG: hsa:10149

STRING: 9606.ENSP00000369198

OMIM: 300572

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