GGCT Antibody, Biotin conjugated

Code: CSB-PA009387LD01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

O75223

Target Names

GGCT

Alternative Names

C7orf24 antibody; CRF21 antibody; Cytochrome c-releasing factor 21 antibody; Gamma glutamyl cyclotransferase antibody; Gamma-glutamylcyclotransferase antibody; GCTG antibody; GGC antibody; Ggct antibody; GGCT_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Gamma-glutamylcyclotransferase protein (54-188AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.

Gene References into Functions

GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients. PMID:29429592
Taken together, the results indicate that PHB2 plays a central role in p21 upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21. PMID:29307834
GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target. PMID:26828272
GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings. PMID:26339607
G6PD, GGCT, IDH1, isocitrate dehydrogenase 2 (NADP+,mitochondrial) (IDH2) and glutathione S-transferase pi 1(GSTP1), five of the critical components of GSH pathway, contribute to chemoresistance. PMID:25818003
GGCT plays a critical role in lung cancer cell proliferation. PMID:25941902
Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region. PMID:23853312
increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression PMID:24342434
C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers. PMID:23513927
GGCT may be a biomarker of tumors in a limited range of organs. PMID:22205682
C7orf24 overexpression defines a subgroup of breast tumors with poor clinical outcome. PMID:20527979
CRF21 might play an important role in the induction of apoptosis by GGO in leukemia U937 cells. PMID:16765912
presence of extra electron density/ligands and conservation at the sequence and structure levels, it is likely that the cavity has a crucial role in the function of LOC79017 and its structural neighbors possibly as an active site or ligand-binding site PMID:17932939
The GGCT gene is located on chromosome 7p14-15 and consists of four exons that span 8 kb, the primary sequence is 188 amino acids in length and is unlike any protein of known function PMID:18515354