GGA2 Antibody

Code: CSB-PA891942ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse, Rat

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9UJY4

Target Names

GGA2

Alternative Names

1200007E24Rik antibody; ADP ribosylation factor binding protein 2 antibody; ADP ribosylation factor binding protein GGA 2 antibody; ADP ribosylation factor binding protein GGA2 antibody; ADP-ribosylation factor-binding protein GGA2 antibody; ARF-binding protein 2 antibody; FLJ20966 antibody; Gamma adaptin related protein 2 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 2 antibody; GGA 2 antibody; Gga2 antibody; GGA2_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF binding protein 2 antibody; Golgi localized gamma ear containing ARF binding protein 2 antibody; Golgi-localized antibody; KIAA1080 antibody; Vear antibody; VHS domain and ear domain containing protein antibody; VHS domain and ear domain of gamma adaptin antibody; VHS domain and ear domain of gamma-adaptin antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human ADP-ribosylation factor-binding protein GGA2 protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: ADP-ribosylation factor-binding protein GGA2 antibody at 10μg/ml
Lane 1: Rat brain tissue
Lane 2: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67 kDa
Observed band size: 67 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA891942ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network.

Gene References into Functions

Study shows that reduced expression of GGA3 resultes in accumulation of endocytosed EGFR within enlarged endosomes. GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Finally, GGA2 was upregulated in 30.8% of human hepatocellular carcinomas and 23.3% of colorectal cancers. PMID:29358589
PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization. PMID:28289207
full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. PMID:27901063
These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. PMID:24407285
GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3. PMID:22291915
endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 PMID:12135764
GGA proteins function with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. PMID:15615712
Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles. PMID:17451558
These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. PMID:17494868
p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers. PMID:17596511
GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes PMID:18431031
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. PMID:19788741

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Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.

Protein Families

GGA protein family

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 16064

UNIGENE: Hs.460336

KEGG: hsa:23062

STRING: 9606.ENSP00000311962

OMIM: 606005

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