GDF3 Antibody

CSB-PA006316

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9NR23

Target Names

GDF3

Alternative Names

C78318 antibody; ecat9 antibody; GDF 3 antibody; GDF-3 antibody; GDF3 antibody; GDF3_HUMAN antibody; Growth differentiation factor 3 antibody; Growth/differentiation factor 3 antibody; KFS3 antibody; MCOP7 antibody; MCOPCB6 antibody; MGC123990 antibody; MGC123991 antibody; RGD1564178 antibody; Vgr 2 antibody; Vgr2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human GDF-3.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

Western Blotting(WB) Protocol ELISA Protocol

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of L929 cells using GDF-3 Polyclonal Antibody
Western Blot analysis of L929 cells using GDF-3 Polyclonal Antibody

Description

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Target Background

Function

Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto. Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto.

Gene References into Functions

the 4 of the 5 variants in [i]GDF3[/i] gene contribute different pathogenicity in congenital scoliosis, which may provide molecular evidence for clinical genetic testing. PMID:29735971
OCT4 plays a role as a transcriptional activator for GDF3 transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis. PMID:27803451
The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs. PMID:25372014
first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells PMID:22963770
GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues. PMID:22488170
the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation PMID:21805089
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells. PMID:22305102
Mutation of GDF3 causes ocular and skeletal anomalies. PMID:19864492
Present data suggested that GDF3 might play important roles in the central nervous system (CNS), especially in cerebral cortex, hippocampus and cerebellum, and it shed new light on further research of GDF3 in the central nervous system. PMID:16126341
GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types. PMID:16339188
GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID:18480259
GDF3 is either a bi-functional TGF-beta ligand, or, more likely, that it is a BMP inhibitor that can artificially activate Nodal signaling under non-physiological conditions. PMID:18823971
GDF3 positivity is helpful in the diagnosis of yolk sac tumor PMID:19396148