GABBR2 Antibody

1. GABA B receptor expression in myometrium PMID:30343129
2. We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma PMID:28490462
3. There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. PMID:28118741
4. Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders. PMID:28867141
5. GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. PMID:28856709
6. Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit. PMID:28323850
7. a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. PMID:27033668
8. The rare variants in GABBR2 were significantly associated with smoking status. PMID:25450229
9. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID:24682435
10. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. PMID:24923912
11. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID:24778228
12. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID:24482233
13. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. PMID:22169202
14. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID:22613715
15. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system. PMID:22660477
16. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID:21971078
17. Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. PMID:21724853
18. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders. PMID:21303731
19. GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. PMID:20557420
20. variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations PMID:19763258
21. Increased expression of GABA(B) receptor subtype 2 indicates augmented presynaptic inhibition of glutamate release as a possible protective mechanism in temporal lobe epilepsy. PMID:14625043
22. GABA(B) receptor subunit GABA(B)R2 is found on the same neurons and follows the same distribution patterns in the basal ganglia as the GABABR1 receptor subunit. PMID:14961561
23. Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit robustly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, that is usually required for efficient trafficking of GABA(B)R1 to the cell surface. PMID:14966130
24. The GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon. PMID:14978362
25. Functional GABA(B) receptors are expressed in human airway smooth muscle cells PMID:16829628
26. GABA(B) receptor stability and signaling can be modulated via GABA(B) receptor subunit 2 interactions with the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABA(B) receptors in the central nervous system. PMID:17145756
27. Levels of GABBR1 are significantly decreased in the cerebellum of patients with autism. PMID:19002745

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HGNC: 4507

UNIGENE: Hs.198612

KEGG: hsa:9568

STRING: 9606.ENSP00000259455

OMIM: 607340