FTCD Antibody

Code: CSB-PA009029ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

O95954

Target Names

FTCD

Alternative Names

Formimidoyltetrahydrofolate cyclodeaminase antibody; Formimidoyltransferase cyclodeaminase antibody; Formiminotetrahydrofolate cyclodeaminase antibody; Formiminotransferase cyclodeaminase antibody; Formiminotransferase-cyclodeaminase antibody; FTCD antibody; FTCD_HUMAN antibody; Glutamate formiminotransferase antibody; Glutamate formyltransferase antibody; LCHC 1 antibody; LCHC1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: FTCD antibody at 5.46μg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 59, 62, 53, 17 kDa
Observed band size: 59 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009029ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009029ESR2HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.

Gene References into Functions

The formiminotransferase-cyclodeaminase allelic spectrum comprised of 12 distinct variants including 5 missense alterations, an in-frame deletion, two frameshift variants and four nonsense variants with the remaining alterations predicted to affect mRNA processing/stability. PMID:29178637
FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells PMID:24686083
The FTCD promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID:20494980
Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID:20209057
Disease-causing mutations have been identified in the FTCD gene in three patients with the putative autosomal recessive disorder glutamate formiminotransferase deficiency. PMID:12815595

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Note=More abundantly located around the mother centriole.

Protein Families

Cyclodeaminase/cyclohydrolase family; Formiminotransferase family

Database Links

HGNC: 3974

UNIGENE: Hs.415846

KEGG: hsa:10841

STRING: 9606.ENSP00000291670

OMIM: 229100

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