FRS2 (Ab-196) Antibody

1. loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. PMID:29540482
2. These findings suggest that FRS2 is amplified consistently in liposarcoma. PMID:29368794
3. MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen PMID:27533459
4. we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. PMID:28077787
5. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. PMID:26096936
6. Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. PMID:25368431
7. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. PMID:25900027
8. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID:20184660
9. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. PMID:24284065
10. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. PMID:24706887
11. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA. PMID:22151832
12. Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. PMID:23393200
13. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID:21793095
14. Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts PMID:21233699
15. Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways. PMID:19652666
16. FRS2 has a role in fibroblast growth factor-2-induced signaling PMID:12571252
17. findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point PMID:12974390
18. Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2. PMID:17145761
19. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID:18189271
20. a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling. PMID:19103595
21. Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling. PMID:19111446

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HGNC: 16971

UNIGENE: Hs.593446

KEGG: hsa:10818

STRING: 9606.ENSP00000299293

OMIM: 607743