TENT5C Antibody

Code: CSB-PA736203LA01HU

Rate （5.0）
Review （1）
Citation （1）

Size:

20μg50μg100μg

US$83

Quantity:

Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC, IF

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Product Details
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Target Background

Product Details

Uniprot NO.

Q5VWP2

Target Names

TENT5C

Alternative Names

FA46C_HUMAN antibody; Fam46c antibody; Family with sequence similarity 46 member C antibody; Protein FAM46C antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Terminal nucleotidyltransferase 5C protein (1-391AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: TENT5C antibody at 2 μg/ml + Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45 kDa
Observed band size: 45, 35 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA736203LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA736203LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : WB

Sample type: Human Cell

Review: Immunoblot analysis in FAM46C-overexpressing OPM2 cells. Left: representative blots; right: quantification of band intensities (mean ± SEM; n = 3).

By Anonymous

Citations

The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis C Fucci,/,2020

Target Background

Function(From Uniprot)

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

Gene References into Functions

Study shows that FAM46C, a tumor suppressor for hepatocellular carcinoma, is important for the anti-proliferation and proapoptotic effects of norcantharidin. PMID:28341836
Reduced FAM46C mRNA expression levels were associated with Gastric Cancer. PMID:27770343
data strengthen the growing evidence that the FAM46C gene is involved in the pathogenesis of MM as a potential tumour suppressor, although its role remains to be clarified. PMID:26456599
FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of endoplasmic reticulum response transcripts. PMID:28931820
FAM46C mutation as a contributor to myeloma pathogenesis and disease progression via perturbation in plasma cell differentiation and endoplasmic reticulum homeostasis. PMID:28619709
Data indicate that when cases with FAM46C deletion or mutation were considered together, they were strongly associated with impaired overall survival (OS) in the intensive treatment setting. PMID:21994415