FABP6 Antibody

Code: CSB-PA007955ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

P51161

Target Names

FABP6

Alternative Names

Fabp6 antibody; FABP6_HUMAN antibody; Fatty acid binding protein 6; ileal (gastrotropin) antibody; Fatty acid-binding protein 6 antibody; Gastrotropin antibody; GT antibody; I 15P antibody; I BABP antibody; I BALB antibody; I BAP antibody; I-15P antibody; I-BABP antibody; I15P antibody; IBABP antibody; IBALB antibody; IBAP antibody; ILBP antibody; ILBP3 antibody; Ileal lipid binding protein antibody; Ileal lipid-binding protein antibody; ILLBP antibody; Intestinal 15 kDa protein antibody; Intestinal bile acid binding protein antibody; Intestinal bile acid-binding protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Gastrotropin protein (1-128AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007955ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion.; Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Gene References into Functions

Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR PMID:26613247
Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments. PMID:25073073
show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations PMID:23758264
Ursodeoxycholic acid induces unique conformational changes in IBABP. PMID:22223860
NMR data are in agreement with a conformational selection model we proposed earlier for I-BABP and support the hypothesis of an allosteric mechanism of ligand binding PMID:22329738
The-putative functional-Thr79Met substitution of FABP6 confers a protective effect on type 2 diabetes in obese individuals. PMID:19744871
NMR structure of human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures PMID:12486725
the I-BABP gene may be a novel target for PPAR in humans PMID:15936983
ASBT and ILBP protein were 48% and 67% lower in normal weight gallstone carriers than in controls (P < 0.05); similar differences were found for mRNA expression levels. PMID:16237211
The expression of FABP6 was higher in primary colorectal cancers and adenomas than in normal epithelium, but was dramatically decreased in lymph node metastases, suggesting that FABP6 may play an important role in early carcinogenesis. PMID:16951225
In keeping with its role in the enterohepatic circulation and ileal reabsorption of bile acids, the gene promoter contains consensus elements for CDX2 and FXR. More than one transcription start site has been identified. PMID:14654244

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Subcellular Location

[Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 2]: Cytoplasm.

Protein Families

Calycin superfamily, Fatty-acid binding protein (FABP) family

Tissue Specificity

Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in c

Database Links

HGNC: 3561

UNIGENE: Hs.519719

KEGG: hsa:2172

STRING: 9606.ENSP00000377549

OMIM: 600422

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