DSE Antibody, Biotin conjugated

Code: CSB-PA890925LD01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q9UL01

Target Names

DSE

Alternative Names

Chondroitin glucuronate 5 epimerase antibody; Chondroitin-glucuronate 5-epimerase antibody; Dermatan sulfate epimerase antibody; Dermatan-sulfate epimerase antibody; DS epimerase antibody; DSE antibody; DSE_HUMAN antibody; DSEPI antibody; OTTHUMP00000040406 antibody; SART 2 antibody; SART-2 antibody; Squamous cell carcinoma antigen recognized by T cells 2 antibody; Squamous cell carcinoma antigen recognized by T-cells 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dermatan-sulfate epimerase protein (23-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.

Gene References into Functions

Study showed that DSE is frequently upregulated in human glioma tissue and cell lines and associated with a worse tumor grade and poor overall survival. Its knockdown suppresses malignant phenotypes, whereas DSE overexpression enhances glioma cell malignancy, both in vitro and in vivo. Mechanically, DSE modulates HB-EGF-induced EGFR/ErbB2 activity and downstream signaling. PMID:29864158
study identified a homozygous DSE missense mutation (c.803C>T, p.S268L) in a male child with musculocontractural type of Ehlers-Danlos syndrome; data indicate mutation affects the epimerase activity, resulting in reduced dermatan sulfate (DS) biosynthesis and an increased synthesis or an accumulation or reduced conversion of chondroitin sulfate PMID:23704329
Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma PMID:22350411
Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. PMID:19004833

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Protein Families

Dermatan-sulfate isomerase family

Tissue Specificity

Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Exp

Database Links

HGNC: 21144

UNIGENE: Hs.458358

KEGG: hsa:29940

STRING: 9606.ENSP00000332151

OMIM: 605942

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