DNASE1L3 Antibody

Code: CSB-PA115883

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB

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Product Details
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Target Background

Product Details

Uniprot NO.

Q13609

Target Names

DNASE1L3

Alternative Names

Deoxyribonuclease gamma antibody; Deoxyribonuclease I like 3 antibody; Deoxyribonuclease I like III antibody; Deoxyribonuclease I-like 3 antibody; DHP 2 antibody; DHP2 antibody; DNAS1L3 antibody; DNase gamma antibody; DNase I homolog protein 2 antibody; DNase I homolog protein DHP2 antibody; DNase I like 3 antibody; DNase I-like 3 antibody; DNASE1L3 antibody; DNSL3_HUMAN antibody; Liver and spleen DNase antibody; LS DNase antibody; LS-DNase antibody; LSD antibody; SLEB 16 antibody; SLEB16 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human DNASE1L3

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HT29 cells, human placenta tissue, Primary antibody: CSB-PA115883(DNASE1L3 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds

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Target Background

Function(From Uniprot)

Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.

Gene References into Functions

The authors found a significant reduction in serum DNase1l3 level in dermatomyositis/polymyositis and systemic lupus erythematosus, which may associate with clinic features and disease activity. PMID:28039554
Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470. PMID:25332064
Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases. PMID:24206041
DNASE1L3 mutations occur in hypocomplementemic urticarial vasculitis syndrome. PMID:23666765
We identified a rare autosomal recessive form of systemic lupus erythematosus, in which autozygome analysis revealed a null mutation in the DNASE1L3 gene PMID:22019780
investigates the distribution of DNASE1L3 gene SNPs in exons of the gene in eight Asian, three African, and three Caucasian populations worldwide using newly devised genotyping methods. PMID:21692081
The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. PMID:12154052
Identification of two functional nuclear localization signals in DNase gamma that have a role in apoptotic DNA fragmentation. PMID:12943533
DNase gamma is involved in the generation of resected double-strand DNA breaks associated with somatic hypermutation PMID:15629432
DNAS1L3 plays an active role in lymphoma cell sensitization to VP-16 and its deficiency may constitute a novel mechanism of drug resistance in these cells PMID:16427601
A Caucasian-specific allele in SNP R206C produces an inactive form of DNase Il3. PMID:19559017
Results distinguish DNase gamma-dependent and CAD/DFF40-dependent DNA fragmentations, and show that even if DNA fragmentation is initiated by CAD/DFF40, DNase gamma is required for the more complete digestion of the genomic DNA in dying cells. PMID:19574717