DIAPH2 Antibody

Code: CSB-PA006891ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

O60879

Target Names

DIAPH2

Alternative Names

Dia 2 antibody; DIA antibody; Dia drome antibody; Dia2 antibody; Diap 2 antibody; Diap2 antibody; DIAP2_HUMAN antibody; DIAPH 2 antibody; Diaph2 antibody; Diaphanous 2 antibody; Diaphanous homolog 2 (Drosophila) antibody; Diaphanous homolog 2 antibody; Diaphanous related formin 2 antibody; Diaphanous-related formin-2 antibody; Diaphanous2 antibody; Diaphorase 2 antibody; Diaphorase2 antibody; DRF 2 antibody; DRF2 antibody; FLJ11167 antibody; OTTHUMP00000024270 antibody; OTTHUMP00000024271 antibody; OTTHUMP00000062171 antibody; POF 2 antibody; POF antibody; POF2 antibody; Protein diaphanous homolog 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein diaphanous homolog 2 protein (1-120AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: DIAPH2 antibody at 4.75μg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 126, 125 kDa
Observed band size: 126 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006891ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA006891ESR1HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.

Gene References into Functions

Low DIA2 expression is associated with breast cancer. PMID:29596520
DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans. PMID:24037343
In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID:23620398
Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID:23024796
Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2) PMID:22685410
Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD. PMID:21386871
Dia2 plays an important role in formation of lamellipodia. PMID:18044991

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Subcellular Location

[Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

Protein Families

Formin homology family, Diaphanous subfamily

Tissue Specificity

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Database Links

HGNC: 2877

UNIGENE: Hs.226483

KEGG: hsa:1730

STRING: 9606.ENSP00000321348

OMIM: 300108

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