DGKD Antibody

Code: CSB-PA002129

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, IHC, IF, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q16760

Target Names

DGKD

Alternative Names

DGKD antibody; KIAA0145Diacylglycerol kinase delta antibody; DAG kinase delta antibody; EC 2.7.1.107 antibody; 130 kDa diacylglycerol kinase antibody; Diglyceride kinase delta antibody; DGK-delta antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the N-terminal region of Human DGK-δ.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

WB, IHC, IF, ELISA

Protocols

Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of HuvEc cells using DGK-δ Polyclonal Antibody

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Target Background

Function(From Uniprot)

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.

Gene References into Functions

purification and characterization of DGKepsilon's enzymatic and conformational properties PMID:28199087
Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2. PMID:23184957
This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population. PMID:22406787
Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane. PMID:20857926
Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8. PMID:20064931
Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions PMID:12200442
Phosphorylation is involved in the control of subcellular localization of DGKdelta1. PMID:15228384
Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice. PMID:17357084
Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients. PMID:18267070
Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. PMID:18334213