Ctsk Antibody

Code: CSB-PA006192LA01RA

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20μg50μg100μg

US$83

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Species Reactivity: Rat

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

O35186

Target Names

Ctsk

Alternative Names

Ctsk antibody; Cathepsin K antibody; EC 3.4.22.38 antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Cathepsin K protein (115-329AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:10-1:100

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006192LA01RA at dilution of 1:20

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Target Background

Function(From Uniprot)

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

Gene References into Functions

the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin PMID:29207029
cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies PMID:14585819
In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance. PMID:17181996
Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. PMID:18664521
The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined. PMID:18974601