Cd74 Antibody

1. House dust mites sensitization lowered humoral immune responses to intact pneumococcus and this effect was significantly modified by the HLA-DR polymorphism. PMID:27506953
2. Data highlight the complexity of the MIF/CD74 signaling pathway in the development of mesothelioma. PMID:26883190
3. We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a(-/-) mice, further supporting a CD74-intrinsic effect. PMID:28550201
4. CLIP expression and activated gamma-delta T cells are responsible for the development of preeclampsia. PMID:28642294
5. MIF-CD74 signaling inhibits interferon (IFN)-gamma secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF signaling or its receptor CD74 promotes IFN-gamma release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown. PMID:27157615
6. Ii mediated pathways play a vital role in the initiation and propagation of liver inflammation. PMID:27371158
7. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction. PMID:27199465
8. explored CD74 expression, which can form a complex with CD44, in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis PMID:27463800
9. might play roles in both the middle ear and inner ear in lipopolysaccharide-induced otitis media PMID:27181906
10. Data show that cathepsins S (CatS) regulates CCL2 chemokine expression by modulation of CD74 antigen processing. PMID:26358505
11. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis. PMID:26524976
12. CD74 plays a critical role in the MIF inhibition of osteoclastogenesis. PMID:23044992
13. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II. PMID:26195549
14. SPPL2a-mediated processing of CD74 NTF is indispensable to maintain appropriate levels of tonic BCR signaling to promote B cell maturation. PMID:26157172
15. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74 PMID:25329434
16. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina. PMID:24974304
17. In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production. PMID:25172501
18. MIF promotes the migration of B cells through a ZAP-70-dependent pathway mediated by cooperative engagement of CXCR4 and CD74. PMID:24760155
19. These results demonstrate natural antagonist activity of DRalpha1 for macrophage migration inhibitory factor PMID:24683185
20. Recombinant vaccinia virus vaccines encoding CD74 may be useful tools to improve CD4 T-cell responses to viral and tumour antigens. PMID:24205828
21. Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection. PMID:23896945
22. These findings implicate binding of recombinant T-cell receptor ligand constructs to CD74 as a key step in both antigen-driven and bystander T-cell tolerance important in treatment of inflammatory diseases. PMID:23026773
23. Data show that human Iip35 isoform (CD74 antigen) is expressed in mouse antigen presenting cells. PMID:22689013
24. regulation of CD74 levels by SPPL2a is indispensable for B cell development PMID:23267015
25. ). Proteolytic processing of CD74 requires SPPL2A. PMID:23267016
26. These results emphasize the importance of Ii in B cell homeostasis and suggest that Iip35 could have regulatory functions. PMID:22966065
27. demonstrate here a CD74-dependent MHC class I cross-presentation pathway in dendritic cells that had a major role in the generation of MHC class I-restricted, cytolytic T lymphocyte responses to viral protein- and cell-associated antigens PMID:22306692
28. The cytokine midkine and its receptor RPTPzeta regulate B cell survival in a pathway induced by CD74. PMID:22140262
29. MIF promoted the phosphorylation of AMP-activated protein kinase (AMPK) in a CD74-dependent manner and, in turn, inhibition of AMPK reversed the inhibition of PDGF-induced hepatic stellate cell activation by MIF. PMID:21969590
30. iNKT developed in Ii(-/-) but not catS(-/-) mice have defective effector function. PMID:21565221
31. Data demonstrate that MIF and CD74 play previously unappreciated roles in CCL2-induced macrophage adhesion and migration. PMID:21411731
32. this study emphasizes the role of microvesicles and Ii in the communication between DC and microglia. PMID:20816669
33. although other regions of Ii interact with class II, CLIP binding to the groove is likely to be a dominant event in assembly of nascent class II molecules with Ii in the ER PMID:20547545
34. expression and function of CD74 in normal colon epithelial cells and colon carcinoma cells PMID:20614481
35. Data show that D74-HGF/c-Met axis defines a novel physiologic survival pathway in mature B cells, resulting in the control of the humoral immune response. PMID:20639480
36. We here identify Cd74 as a common insertion site in murine B-lymphomas PMID:20416035
37. Preferential Th1 immune response in invariant chain knockout mice PMID:11823488
38. structure for the trimeric MHC class II-associated invariant chain transmembrane domain PMID:12126629
39. Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chain. PMID:12165499
40. major histocompatibility complex class II-associated invariant chain controls the activity of extracellular cathepsin L PMID:12417635
41. Ii and its isoforms are essential to mediate ovalbumin-induced pulmonary inflammation, IgE generation, and airway hyperresponsiveness in a Th2-dependent immune response. PMID:12538710
42. Expression of Ii blocks constitutive major histocompatibility (MHC) class II localization to plasma membrane lipid rafts and may reduce vaccine efficiency of M12.C3 B cell lymphoma and SaI-Ak sarcoma tumor vaccine cells. PMID:14707062
43. Ii deficiency induces cell autonomous defects of two distinct B cell lineages: the life span of mature follicular B cells is reduced, accounting for their markedly decreased frequency, whereas, in contrast, marginal zone B cells accumulate. PMID:14764672
44. In p41 CD74 isoform-transgenic mice on an I-A(d) background (p41-I-A(d) mice), the recovery from CNS injuries was worse than that of controls. PMID:17182551
45. Ii siRNA-transfected H-2(K) DCs enhanced Th1 responses. PMID:17296316
46. These results suggest that invariant chain-chondroitin sulfate may play an important role in the generation of cell-surface pools of invariant chain that can serve as receptors for CD44 and macrophage migration inhibitory factor. PMID:17492940
47. Ii-Key modified HER-2/neu776-790 hybrid peptides are sufficiently potent to provide antigen-specific CD4+ TH cells with therapeutic antitumor activity PMID:17634957
48. the CD74/NF-kappaB/TAp63 axis defines a novel antiapoptotic pathway in mature B cells, resulting in the shaping of both the B-cell repertoire and the immune response PMID:17846227
49. impact of allelic variation in CLIP affinity on immune responses will be highest in cells with limited DM activity PMID:17947664
50. NOS2 interacts with CD74 (the MHC II-associated invariant chain), and the degradation of CD74 by caspases in immature dendritic cells was inhibited upon treatment with nitric oxide donor. PMID:18003616

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UNIGENE: Mm.439737

KEGG: mmu:16149

STRING: 10090.ENSMUSP00000095171