CTNNA2 Antibody

Code: CSB-PA006165LA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IF

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Target Background

Product Details

Uniprot NO.

P26232

Target Names

CTNNA2

Alternative Names

Alpha catenin related protein antibody; Alpha N catenin antibody; Alpha N-catenin antibody; Alpha-catenin-related protein antibody; Cadherin associated protein related antibody; Cancer/testis antigen 114 antibody; CAP R antibody; CAPR antibody; Catenin (cadherin associated protein) alpha 2 antibody; Catenin alpha 2 antibody; Catenin alpha-2 antibody; CT114 antibody; CTNA2_HUMAN antibody; CTNN A2 antibody; CTNNA 2 antibody; CTNNA2 antibody; CTNR antibody; DKFZp686H02198 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Catenin alpha-2 protein (826-939AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunofluorescence staining of Hela cells with CSB-PA006165LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Target Background

Function(From Uniprot)

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.

Gene References into Functions

Single nucleotide polymorphisms in CTNNA2 show associations in Schizophrenia and general cognitive function. PMID:28746715
One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in t PMID:27497070
SNP 50-kb upstream from CTNNA2 was associated with impulsivity in Native American sample. PMID:27167163
Single nucleotide polymorphism in CTNNA2 is associated with breast cancer susceptibility. PMID:25824743
CTNNA2 gene increases the risk of alcohol addiction in White women. PMID:25041903
CTNNA2 and CTNNA3 are tumor suppressor genes frequently mutated in laryngeal carcinomas. PMID:24100690
Common variants in CTNNA2 are associated with excitement-seeking and risk-taking. PMID:22833195
CTNNA2 is differentially regulated by smoking in schizophrenic patients. PMID:18163523
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID:18519826

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell projection, axon. Nucleus.

Protein Families

Vinculin/alpha-catenin family

Tissue Specificity

Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.

Database Links

HGNC: 2510

UNIGENE: Hs.167368

KEGG: hsa:1496

OMIM: 114025

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