CSH1 Antibody

Code: CSB-PA077659

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P0DML2

Target Names

CSH1

Alternative Names

CSH1Chorionic somatomammotropin hormone 1 antibody; Choriomammotropin antibody; Lactogen antibody; Placental lactogen antibody; PL antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human CSH1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA077659(CSH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA077659(CSH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human breast infiltrative duct tissue, Primary antibody: CSB-PA077659(CSH1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds

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Target Background

Function(From Uniprot)

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Gene References into Functions

FGF-2b and hPL-A are promising candidates for regenerative therapy in Diabetes Mellitus by inducing de-differentiation of stem cells modulating pivotal endocrine genes. PMID:29068419
Placental lactogen is expressed but is not translated into protein in breast cancer. PMID:24475273
These results indicate that placental lactogen induces CYP2E1 expression via PI3-kinase pathway in human hepatocytes. PMID:24408518
Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta. PMID:23744883
altered expression of placenta lactogen appears not to be causal for betamethasone-induced fetal growth restriction in the human PMID:23465880
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. PMID:22387044
Data conclude that members of the C/EBP and Ets families can differentially modulate CS-Benh and CS-Aenh activity. PMID:21737519
hPL-A is involved in the regulation of pancreatic beta cells activity. PMID:21765243
Results strongly support a conformationally mediated obligate-ordered prolactin receptor binding for each of the three lactogenic hormones: prolactin, growth hormone, and placental lactogen. PMID:20427283
The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth. PMID:20233782
Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q. PMID:11897833
a role for CSH1 haploinsufficiency in the etiology of growth retardation PMID:14642004
These data implicate ETS-domain family members in the regulation of the CS locus in placenta and pituitary cells. PMID:14673137
We showed that intra-arterial infusion of human placental lactogen primarily decreased coronary, renal & iliac blood flow. Mechanism of this response was shown to be due to inhibition of vasodilatory beta2-adrenergic receptor-mediated effect. PMID:16410683
crystal structure of the free state of human PL has been determined to 2.0 A resolution showing the molecule possesses an overall structure similar to other long chain four-helix bundle cytokines PMID:16546209
The present findings indicate that the concentration of human placental lactogen (hPL) and human chorionic gonadotropin (beta hCG) mRNA is significantly higher in the cellular component of maternal blood samples than in the plasma component. PMID:16950818
A CSH1 deletion carrier with nearly complete hypomethylation at the ICR1 locus had the characteristic clinical signs of Silver Russel syndrome, ruling out a causal relationship. PMID:17400796
Placental lactogen is a novel ligand of stabilin-1. PMID:18292525
Three single nucleotide polymorphisms in CGB5 and CSH1 genes were genotyped for 844 offspring of the cases and controls. Maternal breast cancer risk did not significantly differ by the offspring's carrier status of the three SNPs. PMID:19047151
maternal smoking associated with a reduction in cord blood hPL PMID:19290844