CHPF Antibody

Code: CSB-PA005373GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

Q8IZ52

Target Names

CHPF

Alternative Names

CHPF antibody; CSS2 antibody; UNQ651/PRO1281Chondroitin sulfate synthase 2 antibody; EC 2.4.1.175 antibody; EC 2.4.1.226 antibody; Chondroitin glucuronyltransferase 2 antibody; Chondroitin-polymerizing factor antibody; ChPF antibody; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II antibody; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II antibody; N-acetylgalactosaminyltransferase 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human CHPF

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Gene References into Functions

High CHPF expression is associated with gliomas. PMID:28627702
data suggest that TGF-beta stimulated the expression of ChPF and sGAG synthesis in nucleus pulposus cells through Smad3, RhoA/ROCK1 and the three MAPK signaling pathways. PMID:28608941
CHPF was found to be differentially methylated in human squamous cell carcinomas. PMID:22461910
study reports a novel protein named Klokin 1(a splice variant of chondroitin polymerizing factor) that transports Parkin to the mitochondria; findings indicate that mitochondrial Parkin prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin deficiency PMID:22082830
Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function PMID:20729547
chondroitin polymerizing activity requires concomitant expression of a ChPF with ChSy; coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. PMID:12716890

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Subcellular Location

[Isoform 1]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol.; [Isoform 3]: Cytoplasm, cytosol. Mitochondrion.; [Isoform 2]: Mitochondrion matrix.

Protein Families

Chondroitin N-acetylgalactosaminyltransferase family

Tissue Specificity

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells

Database Links

HGNC: 24291

UNIGENE: Hs.516711

KEGG: hsa:79586

STRING: 9606.ENSP00000243776

OMIM: 610405

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