CEP68 Antibody

Code: CSB-PA005246GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB,IHC,IF

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Target Background

Product Details

Uniprot NO.

Q76N32

Target Names

CEP68

Alternative Names

Centrosomal protein 68kDa antibody; Centrosomal protein of 68 kDa antibody; Cep68 antibody; CEP68_HUMAN antibody; FLJ25920 antibody; FLJ36750 antibody; KIAA0582 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human CEP68

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase.

Gene References into Functions

CEP68 is important in forming rootletin filaments that branch off centrioles and to modulate the thickness of rootletin fibers. PMID:29463719
It has been proposed that the archetypal linker protein Rootletin maintains centrosome cohesion in part through inhibition of VHL-mediated Cep68 degradation. PMID:28089774
The Cep68 protein level needs to be fine-tuned in order to ensure that its direct interactors, such as the microcephaly protein Cep215 and PCNT, function properly. PMID:28578000
Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID:25503564
C-terminal 300-400 amino acids of Cep68 are necessary to localize Cep68 to interphase centrosomes while C-terminal 400-500 amino acids might regulate Cep68 dissociation from centrosomes at mitotic onset. PMID:25704143
CEP68 gene variants may play an important role in MNSAID-UA susceptibility and, despite the different regulatory mechanisms involved depending on the specific affected organ, in the development of hypersensitivity reactions to NSAIDs. PMID:24618698
Findings imply that CEP68 could be a susceptible gene for aspirin intolerance in asthmatics. PMID:21072201
our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID:17570516
data suggest that Cep68 cooperates with rootletin and C-Nap1 in centrosome cohesion. PMID:18042621