CELSR1 Antibody

Code: CSB-PA080041

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: IF, ELISA

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Target Background

Product Details

Uniprot NO.

Q9NYQ6

Target Names

CELSR1

Alternative Names

CELSR1 antibody; CDHF9 antibody; FMI2Cadherin EGF LAG seven-pass G-type receptor 1 antibody; Cadherin family member 9 antibody; Flamingo homolog 2 antibody; hFmi2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human CDHF9.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene References into Functions

Patients with CELSR1 mutations and spina bifida can have significant renal malformations. PMID:27597235
This single-nucleotide polymorphism-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for Chronic obstructive pulmonary disease. PMID:27854507
Upregulating CELSR1 expression significantly promoted cell growth, while knocking down CELSR1 inhibited the growth and decreased tube formation. PMID:27301287
Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID:25855559
the present study has proven for the first time that CELSR1 is a susceptibility gene for ischaemic stroke in the Chinese Han population, especially for large artery atherosclerosis. PMID:25117632
CELSR1 mutations contribute to the risk of spina bifida in a cohort of spina bifida patients from California PMID:24632739
Celsr1 regulates dynamic cell movements by inhibiting stabilization of VE-cadherin and maturation of adherens junctions. PMID:23792146
CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations. PMID:22371354
Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID:22095531
CELSR1 may have a role in ischemic stroke, as shown in a Portuguese case-control cohort PMID:21511255
The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. PMID:20223754
Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. PMID:19403135
exclusion as a candidate gene for schizophrenia-- a cadhrin gene PMID:11807409
Variations in the nine ectodomains of CELSR1 do not increase susceptibility to schizophrenia. PMID:12782967