CDH3 Antibody

1. the evaluation of P-cadherin expression in lymph node metastases is an important predictor of disease outcome in breast cancer axillary lymph node metastases PMID:28084338
2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID:29338041
3. Ophthalmologists should consider the diagnosis of CDH3-related retinopathy in individuals with such clinical features whether or not there is frank hypotrichosis. PMID:26885695
4. Adhesive dimerization of human P-cadherin catalyzed by a chaperone-like mechanism has been described. PMID:27545624
5. Results strongly advocated a pathogenic potential of the novel variants of CDH3 for the HJMD phenotypes. PMID:27456782
6. CDH3-related disease is characterized by a childhood-onset, progressive chorioretinal atrophy confined to the posterior pole. PMID:27386845
7. This study aimed to demonstrate the usefulness of mRNA expression levels of cadherin 3 (CDH3) in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture PMID:27399126
8. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. PMID:26771841
9. The P-cadherin structure and packing arrangement provide new and valuable information towards the complete structural characterization of the cadherin dimerization pathway. PMID:25849494
10. In patients with breast infiltrating ductal carcinoma, P-cadherin was expressed in 40.5% of cases; P-cadherin expression had a negative relationship with the overall survival PMID:26299056
11. results establish a link between aberrant P-cadherin expression and hypoxic, glycolytic and acid-resistant breast cancer cells, suggesting a possible role for this marker in cancer cell metabolism PMID:25269858
12. Downregulation of P-cadherin expression appears to induce tumorigenicity in hepatocellular carcinoma. PMID:25337260
13. P-cadherin is able to potentiate ligand-dependent signaling of insulin-like growth factor 1 receptor in malignant keratinocytes and epidermal growth factor receptor in dysplastic cells. PMID:25322858
14. These findings indicate that HOXA9 contributes to poor outcomes in Epithelial ovarian cancer in part by promoting intraperitoneal dissemination via its induction of P-cadherin. PMID:25023983
15. The X-dimer plays a key role in the specific cell-cell adhesion mediated by human P-cadherin. PMID:24559158
16. Increased expression of CDH3 is associated with colorectal cancer. PMID:23682078
17. Loss of P-cadherin expression is associated with oral squamous cell carcinoma. PMID:23740836
18. P-cadherin and vimentin could be adjunctive to the commonly used immunohistochemical surrogates for basal-like breast cancer identification PMID:24139214
19. High CDH3 expression is associated with aggressive breast tumour behaviour. PMID:23405208
20. P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3beta-mediated canonical Wnt signaling. PMID:23334344
21. LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin PMID:22531681
22. Hypotrichosis associated with juvenile macular dystrophy is caused by mutations in CDH3, which encodes P-cadherin, a member of the classic cadherin family. PMID:23143461
23. P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-beta2. PMID:22696062
24. Compared with conventional carcinomas, serrated adenocarcinomas showed no significant difference in P-cadherin staining. PMID:22209340
25. A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy PMID:22348569
26. High P-cadherin promotes liver metastasis and is associated with colon cancer. PMID:21703417
27. P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. PMID:21317933
28. a novel splice site mutation (c.IVS10-1 G --> A) in intron 10, which leads to skipping of exon 11 in CDH3 gene in family with hypotrichosis with juvenile macular dystrophy PMID:20140736
29. P-cadherin positivity is associated with high-grade breast cancer subtypes and well-established markers of poor prognosis. PMID:20852590
30. Stable knockdown of P-cadherin in RT-112 cells diminished invasion and migration, and promoted intercellular adhesion PMID:20473917
31. Data conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells. PMID:20860798
32. P-cadherin and CD24 are expressed in carcinomas of the biliary tract with high frequency and at an early stage of carcinogenesis. PMID:20621328
33. Overexpression of CDH3 is associated with basal-like phenotype in breast cancer. PMID:19882246
34. C/EBPbeta is able to up-regulate CDH3 promoter activity in breast cancer cells; the expression of P-cadherin linked with a worse prognosis of breast cancer patients PMID:20385540
35. 2 splice site mutations (one novel and one recurrent mutation) were in the CDH3 gene leading to hypotrichosis with juvenile macular dystrophy. PMID:20203473
36. P-cadherin gene expression proved to be a significant independent prognostic factor for both cancer-specific and recurrence-free survival in bladder cancer PMID:20204300
37. high levels of 80 kDa sP-cadherin in human milk. PMID:11891861
38. results point to the close relationship between the de novo expression of P-cadherin and the disruption of the cadherin/catenins complex with the squamoid phenotype of mucoepidermoid carcinoma of the thyroid (MECT) PMID:12021924
39. may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner PMID:12112590
40. Regulated expression of P-cadherin/beta-catenin complexes in ovarian tumor cells may represent a key step in disease progression PMID:12800191
41. Inappropriate PCAD expression in mouse mammary epithelium is compatible with normal mammary gland function. PMID:12919105
42. An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma. PMID:15375751
43. In summary, we have ascertained a third gene associated with ectrodactyly and have demonstrated a hitherto unrecognised role of CDH3 in shaping the human hand PMID:15805154
44. A short truncated 50 kDa form of the N-terminal part of P-cadherin expresses in melanoma cell lines compared to melanocytes and keratinocytes. PMID:15817166
45. P-cadherin may have a role in progression of oral squamous cell carcinoma PMID:15967043
46. P-cadherin expression was strongly associated with tumor aggressiveness, being a good indicator of clinical outcome, and the aberrant expression of P-cadherin in breast cancer might be regulated by gene promoter hypomethylation. PMID:16115928
47. Novel heterozygous CDH3 mutations in hypotrichosis with juvenile macular dystrophy in two nonconsaguineous families. PMID:17342797
48. P-cadherin may be regarded as an additional immunohistochemical marker of basal-like breast carcinomas. PMID:18074863
49. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans. PMID:18199584
50. Tunisian IBCs are characterized by frequent basal and ERBB2 phenotypes. Surprisingly, luminal inflammatory breast cancer also express the basal marker P-cadherin. PMID:18230143

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HGNC: 1762

UNIGENE: Hs.191842

KEGG: hsa:1001

STRING: 9606.ENSP00000264012

OMIM: 114021